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Cyclic-di-GMP disodium

Name: Cyclic-di-GMP disodium
Brand: TargetMol
SKU: T36983
Price: 139 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T36983Cas No. 2222132-40-1

Alias cyclic diguanylate disodium, Cyclic di-GMP (sodium salt), c-di-GMP disodium, 5GP-5GP disodium, 3',5'-Cyclic diguanylic acid

Cyclic-di-GMP disodium (5GP-5GP disodium) is a STING agonist and a second messenger in bacteria. It is involved in a variety of processes in prokaryotes, including biofilm formation, motility, and cell cycle progression. Cyclic-di-GMP disodium (5GP-5GP disodium) exhibits antiproliferative activity against cancer cells, inducing increased CD4 receptor expression and cell cycle arrest, and is a novel therapeutic agent that can be developed to prevent or treat cancer.

Cyclic-di-GMP disodium

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Purity: 99.93%

Catalog No. T36983Alias cyclic diguanylate disodium, Cyclic di-GMP (sodium salt), c-di-GMP disodium, 5GP-5GP disodium, 3',5'-Cyclic diguanylic acidCas No. 2222132-40-1

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$139	In Stock	In Stock
5 mg	$372	In Stock	In Stock
10 mg	$513	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.93%

Appearance:Solid

Color:Yellow

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COA HPLC HNMR

Product Introduction

Bioactivity

Description	Cyclic-di-GMP disodium (5GP-5GP disodium) is a STING agonist and a second messenger in bacteria. It is involved in a variety of processes in prokaryotes, including biofilm formation, motility, and cell cycle progression. Cyclic-di-GMP disodium (5GP-5GP disodium) exhibits antiproliferative activity against cancer cells, inducing increased CD4 receptor expression and cell cycle arrest, and is a novel therapeutic agent that can be developed to prevent or treat cancer.
In vitro	METHODS: H508 cells were treated with cyclized-di-GMP disodium (5GP-5GP disodium) (0.5-50 μM, 5 days) and cell proliferation was measured using a validated sulforhodamine B (SRB) colorimetric assay. RESULTS The highest concentration (50 μM) of c-di-GMP reduced H508 cell proliferation by approximately 15%. [1] METHODS: Cyclic-di-GMP disodium (5GP-5GP disodium) (50, 100μM) was used to treat Jur kat cells, and the CD4 level in the cells was observed. RESULTS Cyclic-di-GMP disodium (5GP-5GP disodium) at a concentration of 50μM can induce a 6.3-fold increase in CD4 levels in Jur kat cells, and this was dose-dependent. Cyclic-di-GMP disodium (5GP-5GP disodium) at a concentration of 100μM treated Jur kat cells, resulting in a 9.1-fold increase in CD4 compared to the control group. [2]
In vivo	METHODS: Cyclic-di-GMP disodium (5GP-5GP disodium) (100 μg, intravenous injection) was used in mice in the primary and booster phases to verify whether it would further enhance the immune response to TriVax. RESULTS Cyclic-di-GMP disodium (5GP-5GP disodium) can effectively enhance the magnitude of the immune response produced by TriVax. [3]
Synonyms	cyclic diguanylate disodium, Cyclic di-GMP (sodium salt), c-di-GMP disodium, 5GP-5GP disodium, 3',5'-Cyclic diguanylic acid

Chemical Properties

Molecular Weight	734.38
Formula	C₂₀H₂₂N₁₀Na₂O₁₄P₂
Cas No.	2222132-40-1
Smiles	O=C1C2=C(NC(N)=N1)N([C@H]3[C@@H]([C@@]4([H])[C@](COP([O-])(O[C@]5([H])[C@@](O[C@@H](N6C7=C(C(N=C(N7)N)=O)N=C6)[C@@H]5O)([H])COP([O-])(O4)=O)=O)([H])O3)O)C=N2.[Na+].[Na+]
Relative Density.	no data available

Storage & Solubility Information

Storage

store at low temperature,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 144 mg/mL (196.08 mM), Sonication is recommended.

Solution Preparation Table

H2O

	1mg	5mg	10mg	50mg
1 mM	1.3617 mL	6.8085 mL	13.6169 mL	68.0846 mL
5 mM	0.2723 mL	1.3617 mL	2.7234 mL	13.6169 mL
10 mM	0.1362 mL	0.6808 mL	1.3617 mL	6.8085 mL
20 mM	0.0681 mL	0.3404 mL	0.6808 mL	3.4042 mL
50 mM	0.0272 mL	0.1362 mL	0.2723 mL	1.3617 mL
100 mM	0.0136 mL	0.0681 mL	0.1362 mL	0.6808 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc