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Thalidomide 4-fluoride

Catalog No. T7755 CAS 835616-60-9

Synonyms: 2-(2,6-二氧代-哌啶-3-基)-4-氟基-异吲哚-1,3-二酮, E3 ligase Ligand 4

Thalidomide 4-fluoride (Cereblon ligand 4) is the Thalidomide-based Cereblon ligand. Thalidomide 4-fluoride can be used in the recruitment of CRBN protein. Thalidomide 4-fluoride (Cereblon ligand 4) can be connected to the ligand for IRAK4 protein by a linker to form PROTAC IRAK4 degrader-1.

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Thalidomide 4-fluoride, CAS 835616-60-9

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

Synonyms	2-(2,6-二氧代-哌啶-3-基)-4-氟基-异吲哚-1,3-二酮, E3 ligase Ligand 4
Molecular Weight	276.223
Formula	C13H9FN2O4
CAS No.	835616-60-9

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 199 mg/mL (720.44 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Nello Mainolfi, et al. Irak degraders and uses thereof. US20190192668A1.

Related Products

Related compounds with same targets

Zimlovisertib IRAK-4 protein kinase inhibitor 2 JH-X-119-01 Thalidomide 4-fluoride IRAK4-IN-20 HS-243 IRAK inhibitor 6 IRAK inhibitor 1

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Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Thalidomide 4-fluoride 835616-60-9 NF-Kb信号通路免疫与炎症 IRAK Cereblon ligand-4 inhibit Cereblon ligand4 Thalidomide 4fluoride E3 ligase Ligand 4 Inhibitor Thalidomide 4 fluoride Ligands for E3 Ligase Cereblon ligand 4 E3 ligase-recruiting Moiety inhibitor

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