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Tenatoprazole

Catalog No. T6700 CAS 113712-98-4

Synonyms: TU-199

Tenatoprazole (TU-199), a prodrug of the proton pump inhibitor (PPI) class, can inhibit proton transport (IC50: 3.2 μM).

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Tenatoprazole, CAS 113712-98-4

Pack Size	Availability	Price/USD
10 mg	In stock	$ 47.00
25 mg	In stock	$ 63.00
50 mg	In stock	$ 76.00
100 mg	In stock	$ 107.00
200 mg	In stock	$ 163.00
500 mg	In stock	$ 278.00
1 mL * 10 mM (in DMSO)	In stock	$ 39.00

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Purity: 100%

Biological Description

Chemical Properties

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Description	Tenatoprazole (TU-199), a prodrug of the proton pump inhibitor (PPI) class, can inhibit proton transport (IC50: 3.2 μM).
Targets&IC50	Proton transport:3.2 μM
In vitro	Tenatoprazole labeled only the gastric H+,K+-ATPase alpha-subunit as has been found for other PPIs, approximately 2.6 nmol/mg of tenatoprazole is bound to the H+,K+-ATPase. The two enantiomers (R)- or (S)-tenatoprazole give the same stoichiometry of binding with 88% inhibition. Tenatoprazole labels only the peptide containing fifth and sixth transmembrane segments, these contain two cysteines, cysteine 813 in the luminal vestibule and cysteine 822 in the sixth transmembrane domain. [1]
In vivo	Tenatoprazole provides slow activation in vivo, which is predicted by its chemical activation rate in fasting rats. Tenatoprazole inhibits about 20–30% of enzyme activity even though acid secretion in fasting rats. (S)-tenatoprazole sodium salt hydrate provides a higher Cmax of 183 ng/mL, Tmax of 1.3 hours and AUC of 822 ng*h/mL in dog. [1]

Synonyms	TU-199
Molecular Weight	346.4
Formula	C16H18N4O3S
CAS No.	113712-98-4

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 43 mg/mL (124.1 mM)

Ethanol: 12 mg/mL (34.6 mM)

H2O: < 1 mg/mL (insoluble or slightly soluble)

References and Literature

1. Shin JM, et al. Biochem Pharmacol, 2006, 71(6), 837-849.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Bioactive Compounds Library Max Target-Focused Phenotypic Screening Library NO PAINS Compound Library Ion Channel Inhibitor Library Anti-Metabolism Disease Compound Library Bioactive Compound Library ReFRAME Related Library Anti-Cancer Compound Library Orally Active Compound Library

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Tenatoprazole 113712-98-4 Membrane transporter/Ion channel Proton pump Proton Pump TU199 Inhibitor gastric ATPase Tsg101 inhibit virus oral secretion TU 199 acid TU-199 inhibitor

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