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Tenatoprazole

(Synonyms: TU-199) Copy Product Info

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Synonyms: TU-199

Catalog No. T6700 Copy Product Info

Purity: 99.57%

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Tenatoprazole (TU-199), a prodrug of the proton pump inhibitor (PPI) class, can inhibit proton transport (IC50: 3.2 μM).

Cas No. 113712-98-4

Pack Size	Price	USA Stock	Global Stock
5 mg	$30	In Stock	In Stock
10 mg	$48	In Stock	In Stock
25 mg	$63	In Stock	In Stock
50 mg	$77	In Stock	In Stock
100 mg	$98	In Stock	In Stock
500 mg	$246	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$32	In Stock	In Stock

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:99.57%

Appearance:Solid

Color:orange

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	Tenatoprazole (TU-199), a prodrug of the proton pump inhibitor (PPI) class, can inhibit proton transport (IC50: 3.2 μM).
Targets & IC50	Proton transport:3.2 μM
In vitro	Tenatoprazole labeled only the gastric H+,K+-ATPase alpha-subunit as has been found for other PPIs, approximately 2.6 nmol/mg of tenatoprazole is bound to the H+,K+-ATPase. The two enantiomers (R)- or (S)-tenatoprazole give the same stoichiometry of binding with 88% inhibition. Tenatoprazole labels only the peptide containing fifth and sixth transmembrane segments, these contain two cysteines, cysteine 813 in the luminal vestibule and cysteine 822 in the sixth transmembrane domain. [1]
In vivo	Tenatoprazole provides slow activation in vivo, which is predicted by its chemical activation rate in fasting rats. Tenatoprazole inhibits about 20–30% of enzyme activity even though acid secretion in fasting rats. (S)-tenatoprazole sodium salt hydrate provides a higher Cmax of 183 ng/mL, Tmax of 1.3 hours and AUC of 822 ng*h/mL in dog. [1]
Synonyms	TU-199

Chemical Properties

Molecular Weight	346.4
Formula	C₁₆H₁₈N₄O₃S
Cas No.	113712-98-4
Smiles	COc1ccc2[nH]c(nc2n1)S(=O)Cc1ncc(C)c(OC)c1C
Relative Density.	1.43 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 250 mg/mL (721.71 mM), Sonication is recommended.

Ethanol: 12 mg/mL (34.64 mM), Sonication is recommended.

H2O: < 1 mg/mL (insoluble or slightly soluble)

In Vivo Formulation

10% DMSO+90% Saline: < 10 mg/mL (28.87 mM), Lower concentrations may be soluble, but exact solubility limit is unknown.

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 10 mg/mL (28.87 mM), Solution.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

Ethanol/DMSO

	1mg	5mg	10mg	50mg
1 mM	2.8868 mL	14.4342 mL	28.8684 mL	144.3418 mL
5 mM	0.5774 mL	2.8868 mL	5.7737 mL	28.8684 mL
10 mM	0.2887 mL	1.4434 mL	2.8868 mL	14.4342 mL
20 mM	0.1443 mL	0.7217 mL	1.4434 mL	7.2171 mL

DMSO

	1mg	5mg	10mg	50mg
50 mM	0.0577 mL	0.2887 mL	0.5774 mL	2.8868 mL
100 mM	0.0289 mL	0.1443 mL	0.2887 mL	1.4434 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 µL Tween 80 and mix well until fully clarified.

3) Add 450 µL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

virusTU199TU 199Tsg101TenatoprazolesecretionProtonpumpProton PumporalInhibitorinhibitgastricATPaseacid

Related Tags: Tenatoprazole chemical structure | Tenatoprazole in vivo | Tenatoprazole in vitro | Tenatoprazole formula | Tenatoprazole molecular weight