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Catalog No. T4644   CAS 79338-84-4
Synonyms: GSK2894512, Benvitimod, WBI 1001

Tapinarof (Benvitimod) is targeted as a topical cream treatment for psoriasis, a chronic autoimmune skin disease.

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Tapinarof Chemical Structure
Tapinarof, CAS 79338-84-4
Pack Size Availability Price/USD Quantity
1 mg In stock $ 34.00
2 mg In stock $ 48.00
5 mg In stock $ 77.00
10 mg In stock $ 126.00
25 mg In stock $ 243.00
50 mg In stock $ 369.00
100 mg In stock $ 549.00
500 mg In stock $ 1,190.00
1 mL * 10 mM (in DMSO) In stock $ 81.00
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Purity: 99.84%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Tapinarof (Benvitimod) is targeted as a topical cream treatment for psoriasis, a chronic autoimmune skin disease.
Targets&IC50 AhR:13 nM(EC50)
In vitro Tapinarof activates the AhR pathway through direct binding. Tapinarof induces nuclear translocation of AhR in immortalized keratinocytes (HaCaT) in a dose-dependent way.
In vivo Tapinarof mediates its anti-inflammatory effects via the AhR pathway in IMQ-treated mice. In mice expressing AhR on a C57Bl/6 background, both Tapinarof and 6-formylindolo(3,2-b)carbazole (FICZ) significantly lower clinical inflammation scores. Conversely, AhR knockout (KO) mice exhibit no such anti-inflammatory response to Tapinarof. FICZ serves as a benchmark in these experiments, demonstrating comparable reduction in inflammation in wild-type mice, but ineffective in AhR KO mice.
Synonyms GSK2894512, Benvitimod, WBI 1001
Molecular Weight 254.32
Formula C17H18O2
CAS No. 79338-84-4


Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 55 mg/mL (216.26 mM)

TargetMolReferences and Literature

1. Smith SH, et al. Tapinarof Is a Natural AhR Agonist that Resolves Skin Inflammation in Mice and Humans. J Invest Dermatol. 2017 Oct;137(10):2110-2119.


1. Han Q, Chen H, Wang L, et al. Systemic Deficiency of GHR in Pigs leads to Hepatic Steatosis via Negative Regulation of AHR Signaling. International Journal of Biological Sciences. 2021, 17(15): 4108-4121. 2. Sun Y, Chen L H, Wang H X, et al. Activation of aryl hydrocarbon receptor ameliorates rosacea-like eruptions in mice and suppresses the TLR signaling pathway in LL-37-induced HaCaT cells. Toxicology and Applied Pharmacology. 2022: 116189.

Related compound libraries

This product is contained In the following compound libraries:
Drug Repurposing Compound Library FDA-Approved & Pharmacopeia Drug Library Apoptosis Compound Library Nonsteroidal Anti-Inflammatory Compound Library Target-Focused Phenotypic Screening Library Anti-Metabolism Disease Compound Library FDA-Approved Drug Library Clinical Compound Library ReFRAME Related Library Bioactive Compound Library

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Tapinarof 79338-84-4 Immunology/Inflammation Metabolism Aryl Hydrocarbon Receptor AhR Inhibitor WBI1001 GSK2894512 inhibit WBI-1001 GSK 2894512 GSK-2894512 Benvitimod WBI 1001 inhibitor