Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Tapinarof (Benvitimod) is targeted as a topical cream treatment for psoriasis, a chronic autoimmune skin disease.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 34.00 | |
2 mg | In stock | $ 48.00 | |
5 mg | In stock | $ 77.00 | |
10 mg | In stock | $ 126.00 | |
25 mg | In stock | $ 243.00 | |
50 mg | In stock | $ 369.00 | |
100 mg | In stock | $ 549.00 | |
500 mg | In stock | $ 1,190.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 81.00 |
Description | Tapinarof (Benvitimod) is targeted as a topical cream treatment for psoriasis, a chronic autoimmune skin disease. |
Targets&IC50 | AhR:13 nM(EC50) |
In vitro | Tapinarof activates the AhR pathway through direct binding. Tapinarof induces nuclear translocation of AhR in immortalized keratinocytes (HaCaT) in a dose-dependent way. |
In vivo | Tapinarof mediates its anti-inflammatory effects via the AhR pathway in IMQ-treated mice. In mice expressing AhR on a C57Bl/6 background, both Tapinarof and 6-formylindolo(3,2-b)carbazole (FICZ) significantly lower clinical inflammation scores. Conversely, AhR knockout (KO) mice exhibit no such anti-inflammatory response to Tapinarof. FICZ serves as a benchmark in these experiments, demonstrating comparable reduction in inflammation in wild-type mice, but ineffective in AhR KO mice. |
Synonyms | GSK2894512, Benvitimod, WBI 1001 |
Molecular Weight | 254.32 |
Formula | C17H18O2 |
CAS No. | 79338-84-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 150 mg/mL
You can also refer to dose conversion for different animals. More
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Tapinarof 79338-84-4 Immunology/Inflammation Metabolism AhR Aryl Hydrocarbon Receptor Inhibitor WBI1001 GSK2894512 inhibit WBI-1001 GSK 2894512 GSK-2894512 Benvitimod WBI 1001 inhibitor