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Tamolarizine

Catalog No. T34782 CAS 93035-32-6

Synonyms: Tamolarizine, Tamolarizine HCl, Tamolarizine free base, NC 1100, NC1100, Tamolarizine dihyrchloride, NC-1100

Tamolarizine (Tamolarizine free base) free base is a novel calcium antagonist.

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Tamolarizine, CAS 93035-32-6

Pack Size	Availability	Price/USD
1 mg	In stock	$ 143.00
5 mg	In stock	$ 360.00
10 mg	In stock	$ 530.00
25 mg	In stock	$ 859.00
50 mg	In stock	$ 1,180.00
100 mg	In stock	$ 1,590.00
500 mg	In stock	$ 3,190.00

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Purity: 97.46%

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Description	Tamolarizine (Tamolarizine free base) free base is a novel calcium antagonist.
In vitro	Tamolarizine (0.1-10 microM) synergistically potentiated the cytotoxicity of doxorubicin for doxorubicin-resistant K562 cells (K562/DXR), but had hardly any synergistic effects in the parental cell line (K562) at the same concentration. Moreover, tamolarizine inhibits the P-glycoprotein pump-efflux activity in a dose-related manner and reduces the expression of the immunoreactive P-glycoprotein in K562/DXR cells as evaluated by cytofluorimetric assay.[1]
In vivo	Tamolarizine (40 mg/kg; rats; immediately after 15-min brain ischemia) showed slight impairment of place learning during the course of this test, they later reached almost the same performance level as the sham-operated group. Selective neuronal loss in the CA1 subfield was much less in the ischemia+tamolarizine group than in the ischemia+saline group. These results indicate that tamolarizine treatment protects the hippocampus from ischemic brain damage and ameliorates place learning impairment.[2]

Synonyms	Tamolarizine, Tamolarizine HCl, Tamolarizine free base, NC 1100, NC1100, Tamolarizine dihyrchloride, NC-1100
Molecular Weight	432.55
Formula	C27H32N2O3
CAS No.	93035-32-6

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Miyake N, et al. Reversal of multidrug resistance in human leukemia K562 by tamolarizine, a novel calcium antagonist. Jpn J Pharmacol. 2000;82(3):265-8. 2. Tamura R, et al. Ameliorative effects of tamolarizine on place learning impairment induced by transient forebrain ischemia in rats. Brain Res. 2000 Jan 17;853(1):81-92. 3. Nomura Y, et al. Synthesis and structure-activity relationships of 2-(4-benzhydryl-1-piperazinyl)-1-phenylethanols as new calcium blockers. Chem Pharm Bull (Tokyo). 1995 Feb;43(2):241-6. 4. Nishijo H, et al. Physiological results of monkey brain ischemia, and protection by a calcium blocker. Brain Res Bull. 1995;37(1):89-101.

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Keywords

Tamolarizine 93035-32-6 Membrane transporter/Ion channel Metabolism Calcium Channel Tamolarizine HCl Tamolarizine free base NC 1100 NC1100 Tamolarizine dihyrchloride NC-1100 inhibitor inhibit

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