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TL-895

Catalog No. T9705 CAS 1415823-49-2

TL-895 is an ATP-competitive, and highly selective irreversible inhibitor of Bruton’s Tyrosine Kinase(<a href="/target/BTK" style="display: inline; color: #c13a36">BTK</a>). TL-895 showed good potency with an IC50 of 1.5 nM and a Ki of 11.9 nM.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

TL-895, CAS 1415823-49-2

Pack Size	Availability	Price/USD
2 mg	In stock	$ 92.00
5 mg	In stock	$ 131.00
10 mg	In stock	$ 212.00
25 mg	In stock	$ 397.00
50 mg	In stock	$ 677.00
100 mg	In stock	$ 1,127.00
200 mg	In stock	$ 1,687.00
500 mg	In stock	$ 2,537.00
1 mL * 10 mM (in DMSO)	In stock	$ 153.00

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	TL-895 is an ATP-competitive, and highly selective irreversible inhibitor of Bruton’s Tyrosine Kinase(BTK). TL-895 showed good potency with an IC50 of 1.5 nM and a Ki of 11.9 nM.
Targets&IC50	BTK:1.5 nM, BTK:11.9 nM(Ki)

Molecular Weight	447.514
Formula	C25H26FN5O2
CAS No.	1415823-49-2

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 250 mg/mL (558.66 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Valeria Di Battista, et al. Genetics and Pathogenetic Role of Inflammasomes in Philadelphia Negative Chronic Myeloproliferative Neoplasms: A Narrative Review. Int J Mol Sci 2. Richard D Caldwell, et al. Discovery of Evobrutinib: An Oral, Potent, and Highly Selective, Covalent Bruton's Tyrosine Kinase (BTK) Inhibitor for the Treatment of Immunological Diseases. J Med Chem. 2019 Sep 12;62(17):7643-7655.

Related compound libraries

This product is contained In the following compound libraries：

Kinase Inhibitor Library Orally Active Compound Library Inhibitor Library Anti-Cancer Clinical Compound Library Anti-Cancer Drug Library Bioactive Compound Library Bioactive Compounds Library Max Anti-Cancer Active Compound Library Clinical Compound Library Anti-Cancer Compound Library

Related Products

Related compounds with same targets

(±)-Zanubrutinib JAK3/BTK-IN-1 Acalabrutinib enantiomer AS-1763 BTK inhibitor 1 (Compound 27) Naluzotan CHMFL-BTK-01 Spebrutinib besylate

Dose Conversion

You can also refer to dose conversion for different animals. More

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Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

Note:

Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

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An example of a molarity calculation using the molarity calculator
What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?
Enter 197.13 into the Molecular Weight (MW) box
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The answer of 19.713 mg appears in the Mass box

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An example of a dilution calculation using the Tocris dilution calculator
What volume of a given 10 mM stock solution is required to make 20ml of a 50 μM solution?
Using the equation C1V1 = C2V2, where C1=10 mM, C2=50 μM, V2=20 ml and V1 is the unknown:
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The answer of 100 microliter (0.1 ml) appears in the Volume (start) box

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

TL-895 1415823-49-2 Angiogenesis Tyrosine Kinase/Adaptors BTK anti-viral Inhibitor Bruton tyrosine kinase TL895 Myelofibrosis Solid Tumor Carcinoma Acute Myeloid Leukemia Btk Cancer TL 895 Sars-CoV2 COVID-19 inhibit inhibitor

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.