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Streptomycin sulfate

Catalog No. T0060 CAS 3810-74-0

Synonyms: Plantomycin, Estreptomicina, Phytomycin

Streptomycin sulfate (Phytomycin) is a sulfate salt of streptomycin that is a protein synthesis inhibitor.

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Streptomycin sulfate, CAS 3810-74-0

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500 mg	In stock	$ 45.00

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Purity: 99.39%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

Streptomycin sulfate (Phytomycin) is a sulfate salt of streptomycin that is a protein synthesis inhibitor.

In vitro

Strain RB1 exhibits an increased susceptibility to streptomycin that correlates positively with the concentration of CV in the growth medium. Furthermore, as the CV concentration rises, both cytochrome aa3 levels and the bacterium's sensitivity to streptomycin simultaneously escalate. It is noteworthy that cytochrome aa3 plays a critical role in the uptake of streptomycin by B. subtilis[1]. Additionally, streptomycin affects tRNA selection, with resistance mutations predominantly located in protein S12; these mutations are typically associated with enhanced specificity in the tRNA selection process[2].

Synonyms	Plantomycin, Estreptomicina, Phytomycin
Molecular Weight	728.68
Formula	C21H39N7O12·3/2H2SO4
CAS No.	3810-74-0

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: 50 mg/mL (68.61 mM)

DMSO: Insoluble

References and Literature

1. McEnroe AS, et al. Correlation between cytochrome aa3 concentrations and streptomycin accumulation in Bacillus subtilis. Antimicrob Agents Chemother. 1984 Oct;26(4):507-12. 2. Sharma, D., et al., Mutational analysis of S12 protein and implications for the accuracy of decoding by the ribosome. J Mol Biol, 2007. 374(4): p. 1065-76. 3. Zhai J, Jiang C, Long C. Two‐step Method for the Construction and Start‐up of a Fungal‐Bacterial Biofilter for Treating Gaseous Toluene[J]. Environmental Progress & Sustainable Energy. 2020: e13404. 4. Mo L, Hong S, Li Y, et al. Sevoflurane inhibited inflammatory response induced by TNF-α in human trophoblastic cells through p38MAPK signaling pathway[J]. Journal of Receptors and Signal Transduction. 2020: 1-6. 5. Li Q, Bian Y, Li Q. Down-Regulation of TMPO-AS1 Induces Apoptosis in Lung Carcinoma Cells by Regulating miR-143-3p/CDK1 Axis[J]. Technology in cancer research & treatment. 2021, 20: 1533033820948880. 6. Huang L, Li Q. Notoginsenoside R1 promotes differentiation of human alveolar osteoblasts in inflammatory microenvironment through inhibiting NF‑κB pathway and activating Wnt/β‑catenin pathway[J]. Molecular Medicine Reports. 2020, 22(6): 4754-4762.

Citations

1. Qu H, Yu Q, Jia B, et al. HIF‑3α affects preeclampsia development by regulating EVT growth via activation of the Flt‑1/JAK/STAT signaling pathway in hypoxia. Molecular Medicine Reports. 2021, 23(1): 1-1. 2. Huang L, Li Q. Notoginsenoside R1 promotes differentiation of human alveolar osteoblasts in inflammatory microenvironment through inhibiting NF‑κB pathway and activating Wnt/β‑catenin pathway. Molecular Medicine Reports. 2020, 22(6): 4754-4762 3. Li Q, Bian Y, Li Q. Down-Regulation of TMPO-AS1 Induces Apoptosis in Lung Carcinoma Cells by Regulating miR-143-3p/CDK1 Axis. Technology in cancer research & treatment. 2021, 20: 1533033820948880. 4. Mo L, Hong S, Li Y, et al. Sevoflurane inhibited inflammatory response induced by TNF-α in human trophoblastic cells through p38MAPK signaling pathway. Journal of Receptors and Signal Transduction. 2020: 1-6 5. Zhai J, Jiang C, Long C. Two‐step Method for the Construction and Start‐up of a Fungal‐Bacterial Biofilter for Treating Gaseous Toluene. Environmental Progress & Sustainable Energy. 2020: e13404 6. Zhang Y, Cai Y, Wang T, et al.A common tolerance mechanism of bacterial biofilms to antibiotics.bioRxiv.2023: 2023.01. 30.526163.

Related compound libraries

This product is contained In the following compound libraries：

Microbial Natural Product Library Toxic Compound Library Approved Drug Library Human Metabolite Library Covalent Natural Product Library Antibiotics Library Natural Product Library FDA-Approved & Pharmacopeia Drug Library NO PAINS Compound Library Clinical Compound Library

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Streptomycin sulfate 3810-74-0 Microbiology/Virology ribosome Antibiotic Antibacterial Bacterial Inhibitor Streptomycin Plantomycin Estreptomicina inhibit Phytomycin Streptomycin Sulfate inhibitor

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