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Sedanolide

Catalog No. T5763 CAS 6415-59-4

Sedanolide is a natural phthalide first isolated from seed oil of the Umbelliferae family, including celery.

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Sedanolide, CAS 6415-59-4

Pack Size	Availability	Price/USD
1 mg	In stock	$ 48.00
5 mg	In stock	$ 108.00
10 mg	In stock	$ 160.00
25 mg	In stock	$ 266.00
50 mg	In stock	$ 395.00
100 mg	In stock	$ 587.00
1 mL * 10 mM (in DMSO)	In stock	$ 120.00

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

Sedanolide is a natural phthalide first isolated from seed oil of the Umbelliferae family, including celery.

In vitro

Sedanolide suppressed J5 cell viability by inducing autophagy. Phosphoinositide 3-kinase (PI3K)-I, mammalian target of rapamycin (mTOR) and Akt protein levels decreased, whereas PI3K-III, LC3-II and Beclin-1 protein levels increased following Sedanolide treatment in J5 cells. In addition, Sedanolide treatment upregulated nuclear p53 and damage-regulated autophagy modulator (DRAM) and downregulated cytosolic p53 and Tp53-induced glycolysis and apoptosis regulator (TIGAR) expression in J5 cells. Furthermore, the cytosolic phosphorylation of inhibitor of kappa B (IκB) and nuclear p65 and the DNA-binding activity of NF-κB increased after Sedanolide treatment. These results suggest that Sedanolide induces J5 cell autophagy by regulating PI3K, p53 and NF-κB autophagy-associated signaling pathways in J5 cells.

Molecular Weight	194.27
Formula	C12H18O2
CAS No.	6415-59-4

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 9 mg/mL (46.33 mM)

References and Literature

1. Hsieh S L , Chen C T , Wang J J , et al. Sedanolide induces autophagy through the PI3K, p53 and NF-κB signaling pathways in human liver cancer cells[J]. International Journal of Oncology, 2015, 47(6).

Related compound libraries

This product is contained In the following compound libraries：

Traditional Chinese Medicine Monomer Library Anti-Inflammatory Traditional Chinese Medicine Compound Library Food as Medicine Compound Library Natural Product Library Bioactive Compound Library Traditional Mongolian Medicine Compound Library Covalent Inhibitor Library Bioactive Compounds Library Max Selected Plant-Sourced Compound Library PBCRBS Traditional Chinese Medicine Compound Library

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Sedanolide 6415-59-4 Autophagy Others inhibit Inhibitor inhibitor

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