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SDMA

Catalog No. T7344 CAS 30344-00-4

Synonyms: NG,NG'-Dimethyl-L-arginine, Symmetric dimethylarginine

SDMA (Symmetric dimethylarginine) is the most potent endogenous inhibitor of nitric oxide synthase (NOS), with higher levels in patients with end-stage renal disease (ESRD).

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SDMA, CAS 30344-00-4

Pack Size	Availability	Price/USD
5 mg	In stock	$ 34.00
10 mg	In stock	$ 55.00
25 mg	In stock	$ 101.00
50 mg	In stock	$ 174.00
100 mg	In stock	$ 274.00
1 mL * 10 mM (in DMSO)	In stock	$ 50.00

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Biological Description

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Description

SDMA (Symmetric dimethylarginine) is the most potent endogenous inhibitor of nitric oxide synthase (NOS), with higher levels in patients with end-stage renal disease (ESRD).

In vitro

SDMA inhibited dose dependently the NO synthesis in intact endothelial cells, whereas it had no effect on protein expression of NOS. This effect was associated with an increase in reactive oxygen species. Co-incubation with L-arginine but not D-arginine reversed the effect of SDMA on NOS pathway. Suggest that SDMA reduced the endothelial NO synthesis, probably by limiting L-arginine supply to NOS. It is concluded that SDMA might be a useful parameter for detecting patients in very early stages of chronic kidney disease and for determining their risk for developing cardiovascular disease[1].

Synonyms	NG,NG'-Dimethyl-L-arginine, Symmetric dimethylarginine
Molecular Weight	202.25
Formula	C8H18N4O2
CAS No.	30344-00-4

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 50 mg/mL (247.22 mM)

References and Literature

1. Bode-Boger, S. M . Symmetrical Dimethylarginine: A New Combined Parameter for Renal Function and Extent of Coronary Artery Disease[J]. Journal of the American Society of Nephrology, 2006, 17(4):1128-1134. 2. Toxic Dimethylarginines: Asymmetric Dimethylarginine (ADMA) and Symmetric Dimethylarginine (SDMA).

Citations

1. Wang Y, Wu M, Chen D, et al.SDMA attenuates renal tubulointerstitial fibrosis through inhibition of STAT4.Journal of Translational Medicine.2023, 21(1): 1-13.

Related compound libraries

This product is contained In the following compound libraries：

Human Endogenous Metabolite Library Inhibitor Library Bioactive Compounds Library Max Bioactive Compound Library Human Endogenous Metabolite Compound Library Plus Natural Product Library Gut Microbial Metabolite Library Human Metabolite Library NO PAINS Compound Library Natural Product Library for HTS

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Keywords

SDMA 30344-00-4 Metabolism Endogenous Metabolite NG,NG'-Dimethyl-L-arginine Symmetric dimethylarginine inhibit Inhibitor inhibitor

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