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SDMA

Catalog No. T7344 CAS 30344-00-4

Synonyms: Symmetric dimethylarginine, NG,NG'-Dimethyl-L-arginine

SDMA is the most potent endogenous inhibitor of nitric oxide synthase (NOS), with higher levels in patients with end-stage renal disease (ESRD).

SDMA, CAS 30344-00-4

Pack Size	Availability	Price/USD
5 mg	In stock	47.00
10 mg	In stock	57.00
25 mg	In stock	113.00
50 mg	In stock	194.00
100 mg	In stock	338.00
1 mL * 10 mM (in DMSO)	In stock	50.00

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Biological Description

Chemical Properties

Storage & Solubility Information

Description	SDMA is the most potent endogenous inhibitor of nitric oxide synthase (NOS), with higher levels in patients with end-stage renal disease (ESRD).
Targets&IC50	Human Endogenous Metabolite,
In vitro	SDMA inhibited dose dependently the NO synthesis in intact endothelial cells, whereas it had no effect on protein expression of NOS. This effect was associated with an increase in reactive oxygen species. Co-incubation with L-arginine but not D-arginine reversed the effect of SDMA on NOS pathway. Suggest that SDMA reduced the endothelial NO synthesis, probably by limiting L-arginine supply to NOS. It is concluded that SDMA might be a useful parameter for detecting patients in very early stages of chronic kidney disease and for determining their risk for developing cardiovascular disease[1].

Synonyms	Symmetric dimethylarginine , NG,NG'-Dimethyl-L-arginine
Purity
Molecular Weight	202.25
Formula	C8H18N4O2
CAS No.	30344-00-4

Storage

0-4℃ for short term (days to weeks), or -20℃ for long term (months).

Solubility Information

DMSO: 50 mg/mL (247.22 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

Citations

References and Literature

1. Bode-Boger, S. M . Symmetrical Dimethylarginine: A New Combined Parameter for Renal Function and Extent of Coronary Artery Disease[J]. Journal of the American Society of Nephrology, 2006, 17(4):1128-1134. 2. Toxic Dimethylarginines: Asymmetric Dimethylarginine (ADMA) and Symmetric Dimethylarginine (SDMA).

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Answers to questions you may have can be found in the Inhibitor Handling Instructions. Topics include how to prepare stock solutions, how to store Products, and issues that need special attention for cell-based assays and animal experiments.

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