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Rosabulin

Catalog No. T16788 CAS 501948-05-6

Synonyms: STA 5312

v Rosabulin (STA 5312) is an orally active microtubule inhibitor with potency. Rosabulin inhibits microtubule assembly and has broad-spectrum antitumor activity.

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Rosabulin, CAS 501948-05-6

Pack Size	Availability	Price/USD
1 mg	In stock	$ 125.00
5 mg	In stock	$ 313.00
10 mg	In stock	$ 497.00
25 mg	In stock	$ 793.00
50 mg	In stock	$ 1,130.00
100 mg	In stock	$ 1,520.00
500 mg	In stock	$ 2,970.00
1 mL * 10 mM (in DMSO)	In stock	$ 345.00

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Purity: 98.06%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	v Rosabulin (STA 5312) is an orally active microtubule inhibitor with potency. Rosabulin inhibits microtubule assembly and has broad-spectrum antitumor activity.
In vitro	Rosabulin is inhibition of microtubule assembly and subsequent arrest of the cell cycle. Rosabulin is active against several tumor cell lines that express moderate to high levels of P-glycoprotein. Rosabulin shows substantial anti-proliferative activity against a wide range of cancer cell lines in vitro, with IC50 values extending down into the nanomolar range.[1]
In vivo	Rosabulin has displayed in vivo activity in several murine tumors as well as human tumor xenograft models.[1]

Synonyms	STA 5312
Molecular Weight	400.45
Formula	C22H16N4O2S
CAS No.	501948-05-6

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 25 mg/mL (62.43 mM), Sonication is recommended.

References and Literature

1. Keizo Koya, et al. STA-5312, a novel tubulin inhibitor, demonstrates the anti-cancer activity against chemotherapy-resistant cancers. Proc Amer Assoc Cancer Res. 2004;45

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Anti-Cancer Active Compound Library Anti-Cancer Clinical Compound Library Drug Repurposing Compound Library Anti-Cancer Drug Library Microtubule-Targeted Compound Library Bioactive Compound Library Anti-Cancer Compound Library Clinical Compound Library Bioactive Compounds Library Max

Related Products

Related compounds with same targets

Tubulysin D Combretastatin A-1 4'-Demethylepipodophyllotoxin MPT0B014 Curvulin Batabulin Parbendazole OSIP-486823

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed n the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Rosabulin 501948-05-6 Cytoskeletal Signaling Others Microtubule Associated STA-5312 STA 5312 STA5312 inhibitor inhibit

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