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Ritonavir

Catalog No. T1525 CAS 155213-67-5

Synonyms: RTV, Abbott 84538, A 84538, ABT 538

Ritonavir (ABT 538) is a peptidomimetic agent that inhibits both HIV-1 and HIV-2 proteases. Ritonavir is highly inhibited by serum proteins but boosts the effect of other HIV proteases by blocking their degradation by cytochrome P450.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

Ritonavir, CAS 155213-67-5

Pack Size	Availability	Price/USD
5 mg	In stock	$ 31.00
10 mg	In stock	$ 45.00
25 mg	In stock	$ 72.00
50 mg	In stock	$ 103.00
100 mg	In stock	$ 148.00
200 mg	In stock	$ 213.00
500 mg	In stock	$ 357.00
1 g	In stock	$ 528.00
1 mL * 10 mM (in DMSO)	In stock	$ 45.00

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Purity: 99.5%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

Synonyms	RTV, Abbott 84538, A 84538, ABT 538
Molecular Weight	720.94
Formula	C37H48N6O5S2
CAS No.	155213-67-5

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 14.4 mg/mL (20 mM), Heating is recommended.

Ethanol: 7.2 mg/mL (10 mM)

References and Literature

1. Eagling VA, et al. Br J Clin Pharmacol, 1997, 44(2), 190-194. 2. Kumar GN, et al. J Pharmacol Exp Ther, 1996, 277(1), 423-431. 3. Weichold FF, et al. J Hum Virol, 1999, 2(5), 261-269. 4. Drewe J, et al. Biochem Pharmacol, 1999, 57(10), 1147-1152. 5. Kumar GN, et al. Drug Metab Dispos, 1999, 27(8), 902-908. 6. Fical L. Vývoj UHPLC-MS/MS metody pro analýzu vybraných antivirotik v HILIC a RP módu[J]. 2020 7. Chu, Liuxi, et al. Simultaneous quantitation of zidovudine, efavirenz, lopinavir and ritonavir in human hair by liquid chromatography-atmospheric pressure chemical ionization-tandem mass spectrometry [J]. Journal of Chromatography B . 2018 Oct 15;1097-1098:54-63. 8. Fical L, Khalikova M, Kočová Vlčková H, et al. Determination of Antiviral Drugs and Their Metabolites Using Micro-Solid Phase Extraction and UHPLC-MS/MS in Reversed-Phase and Hydrophilic Interaction Chromatography Modes[J]. Molecules. 2021, 26(8): 2123.

Citations

1. Cheng C, Ji Z, Sheng Y, et al. Aphthous ulcer drug inhibits prostate tumor metastasis by targeting IKKɛ/TBK1/NF-κB signaling. Theranostics. 2018, 8(17): 4633 2. Wu Y, Chu L, Yang H, et al. Simultaneous Determination of 6 Antiretroviral Drugs in Human Hair Using an LC-ESI+-MS/MS Method: Application to Adherence Assessment. Therapeutic Drug Monitoring. 2021, 43(6): 756-765. 3. Fical L, Khalikova M, Kočová Vlčková H, et al. Determination of Antiviral Drugs and Their Metabolites Using Micro-Solid Phase Extraction and UHPLC-MS/MS in Reversed-Phase and Hydrophilic Interaction Chromatography Modes. Molecules. 2021, 26(8): 2123.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Anti-Cancer Approved Drug Library Drug Repurposing Compound Library Anti-Cancer Drug Library Anti-Cancer Clinical Compound Library EMA Approved Drug Library Anti-Viral Compound Library CNS-Penetrant Compound Library NO PAINS Compound Library FDA-Approved & Pharmacopeia Drug Library

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Dose Conversion

You can also refer to dose conversion for different animals. More

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Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

Note:

Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Ritonavir 155213-67-5 Apoptosis Microbiology/Virology Proteases/Proteasome HIV Protease SARS-CoV SARS coronavirus Human immunodeficiency virus ABT-538 Inhibitor HIV RTV A-84538 Abbott 84538 A84538 A 84538 inhibit ABT 538 ABT538 inhibitor

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.