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Rifabutin

Catalog No. T1501 CAS 72559-06-9

Synonyms: LM-427, Ansamycin

Rifabutin (LM-427) inhibits bacterial DNA-dependent RNA polymerase, thereby suppressing the initiation of RNA formation and leading to inhibition of RNA synthesis and transcription. Rifabutin is a semisynthetic ansamycin antibiotic with potent antimycobacterial properties.

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Rifabutin, CAS 72559-06-9

Pack Size	Availability	Price/USD
25 mg	In stock	$ 42.00
50 mg	In stock	$ 55.00
100 mg	In stock	$ 79.00
200 mg	In stock	$ 141.00
500 mg	In stock	$ 238.00
1 mL * 10 mM (in DMSO)	In stock	$ 50.00

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Purity: 99.8%

Purity: 99.7%

Purity: 99.27%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Rifabutin (LM-427) inhibits bacterial DNA-dependent RNA polymerase, thereby suppressing the initiation of RNA formation and leading to inhibition of RNA synthesis and transcription. Rifabutin is a semisynthetic ansamycin antibiotic with potent antimycobacterial properties.
In vitro	In chimeric mice, the combined use of Rifabutin (100 mg/kg) and emtricitabine (10 mg/kg) resulted in a 75% survival rate among mice infected with either Toxoplasma or Plasmodium. Additionally, in these mice, Rifabutin significantly increased human CYP3A4 mRNA expression (by 7.4-fold), CYP3A4 protein levels (by 3.0-fold), testosterone 6β-hydroxylase activity (by 2.4-fold), and dexamethasone 6-hydroxylase activity (by 1.9-fold).
In vivo	Rifabutin exhibits broad-spectrum antimicrobial activity and, compared to rifampicin, demonstrates higher potency in vitro against the Mycobacterium avium complex (MAC), Mycobacterium tuberculosis, and Mycobacterium leprae. It is also effective against Group A Streptococcus, Campylobacter jejuni, Neisseria gonorrhoeae, Haemophilus influenzae, Staphylococcus species, Haemophilus ducreyi, Helicobacter pylori, Neisseria meningitidis, Chlamydia trachomatis, and Toxoplasma gondii. While rifabutin is active against most atypical mycobacteria, including Mycobacterium kansasii, it is less effective against Mycobacterium chelonae. Its isoenzyme selectivity closely resembles that of rifampicin, although rifampin induces to a greater extent, by 2-4 times. Furthermore, rifabutin enhances the glucuronidation of β-estradiol, 4-hydroxytamoxifen, and 1-naphthol by 2-3 times.

Synonyms	LM-427, Ansamycin
Molecular Weight	847
Formula	C46H62N4O11
CAS No.	72559-06-9

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

Ethanol: 38 mg/mL (44.9 mM)

DMSO: 56 mg/mL (66.1 mM)

References and Literature

1. Kunin CM, et al. Clin Infect Dis, 1996, 22 Suppl 1, S3-13. 2. Oesch F, et al. J Antimicrob Chemother, 1996, 37(6), 1111-1119. 3. Katoh M, et al. Xenobiotica, 2005, 35(9), 863-875. 4. Araujo FG, et al. Antimicrob Agents Chemother, 1994, 38(3), 570-575.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Clinical Compound Library Drug Repurposing Compound Library Inhibitor Library Anti-Cancer Drug Library Anti-Cancer Approved Drug Library Anti-Cancer Compound Library Macrocyclic Compound Library FDA-Approved Drug Library DNA Damage & Repair Compound Library Antibiotics Library

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Rifabutin 72559-06-9 Cell Cycle/Checkpoint Cytoskeletal Signaling DNA Damage/DNA Repair Metabolism Microbiology/Virology Antibacterial Antibiotic DNA/RNA Synthesis HSP inhibit LM-427 Ansamycin Inhibitor Bacterial LM427 LM 427 inhibitor

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