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Rasagiline Mesylate

Catalog No. T6962 CAS 161735-79-1

Synonyms: TVP1012, AGN1135, Azilect

Rasagiline Mesylate (AGN1135) is a novel MAO-B inhibitor, which can treat idiopathic Parkinson's disease.

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Rasagiline Mesylate, CAS 161735-79-1

Pack Size	Availability	Price/USD
25 mg	In stock	$ 38.00
50 mg	In stock	$ 46.00
100 mg	In stock	$ 72.00
200 mg	In stock	$ 97.00

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Purity: 100%

Biological Description

Chemical Properties

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Description	Rasagiline Mesylate (AGN1135) is a novel MAO-B inhibitor, which can treat idiopathic Parkinson's disease.
Targets&IC50	MAO-A:412 nM, MAO-B:4.43 nM
In vitro	Rasagiline inhibits rat brain MAO type B and type A with IC50 of 4.43 nM and 412 nM, respectively. Rasagiline is three to 15 times more potent than selegiline for inhibition of MAO-B in rat brain and liver in vivo on acute and chronic administration, but has similar potency in vitro. [1] Rasagiline prevents nuclear accumulation of GAPDH induced by N-methyl(R) salsolinol in SH-SY5Y cells. Rasagiline prevents the collapse in ΔΨm, and following apoptotic process, which indicates that mitochondria may determine the survival and death of the cells. [2] Rasagiline has potent antiapoptotic and neuroprotective activities in response to serum and NGF withdrawal in partially neuronally differentiated PC12 cells and prevents the fall in mitochondrial membrane potential, the first step in cell death. [3] Rasagiline is metabolized to its major metabolite aminoindan, selegiline gives rise to L-methamphetamine. Rasagiline directly activates PKC-MAP kinase pathway by a concentration and time dependent phosphorylation of p42 and p44 MAP kinase. [4]
In vivo	Rasagiline ex vivo inhibits MAO in the brain and liver with ED50 of 4.43 nM and 412 nM, respectively. [1] Rasagiline (0.2 mg/kg and 1 mg/kg) accelerates the recovery of motor function and spatial memory and reduces the cerebral oedema by about 40-50% in the mouse. [5]

Synonyms	TVP1012, AGN1135, Azilect
Molecular Weight	267.34
Formula	C13H17NO3S
CAS No.	161735-79-1

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: 93.51mM

DMSO: 198.2 mM

References and Literature

1. Youdim MB, et al. Br J Pharmacol, 2001, 132(2), 500-506. 2. Maruyama W, et al. J Neurochem, 2001, 78(4), 727-735. 3. Youdim MB, et al. Ann N Y Acad Sci, 2001, 939, 450-458. 4. Wang D, et al. Cancer Chemother Pharmacol, 2006, 57(1), 97-104. 5. Huang W, et al. Eur J Pharmacol, 1999, 366(2-3), 127-135.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Approved Drug Library Drug Repurposing Compound Library Anti-Cancer Drug Library Anti-Cancer Clinical Compound Library EMA Approved Drug Library Inhibitor Library Anti-Neurodegenerative Disease Compound Library Anti-Metabolism Disease Compound Library Covalent Inhibitor Library Autophagy Compound Library

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Keywords

Rasagiline Mesylate 161735-79-1 Apoptosis Autophagy Metabolism Neuroscience Monoamine Oxidase MAO Rasagiline inhibit TVP1012 AGN 1135 AGN-1135 Inhibitor AGN1135 (R)-AGN1135 Azilect TVP 1012 TVP-1012 inhibitor

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