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Pyrazoloacridine

Catalog No. T28475 CAS 99009-20-8

Synonyms: PD-115934, NSC 366140, NSC-366140, PD 115,934, PD 115934

Pyrazoloacridine (PD 115934) is a nucleic acid binding agent that inhibits the activity of topo I and II with an IC50 of 1.25 μM in K562 cells. Pyrazoloacridine shows anti-cancer activity.

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Pyrazoloacridine, CAS 99009-20-8

Pack Size	Availability	Price/USD
1 mg	In stock	$ 60.00
5 mg	In stock	$ 147.00
10 mg	In stock	$ 239.00
25 mg	In stock	$ 478.00
50 mg	In stock	$ 689.00
100 mg	In stock	$ 982.00
500 mg	In stock	$ 1,960.00
1 mL * 10 mM (in DMSO)	In stock	$ 198.00

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Purity: 98.99%

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Description	Pyrazoloacridine (PD 115934) is a nucleic acid binding agent that inhibits the activity of topo I and II with an IC50 of 1.25 μM in K562 cells. Pyrazoloacridine shows anti-cancer activity.
In vitro	In oxic and hypoxic HCT-8 cells, Pyrazoloacridine exhibits IC50 values of 10.7 μM and 4.5 μM[2]. Pyrazoloacridine causes delayed DNA fragmentation in MCF-7 cells and induces apoptosis in P53-deficient Hep 3B cells. Pyrazoloacridine exhibits activities against cisplatin- and paclitaxel-resistant ovarian cancer[3].

Synonyms	PD-115934, NSC 366140, NSC-366140, PD 115,934, PD 115934
Molecular Weight	367.4
Formula	C19H21N5O3
CAS No.	99009-20-8

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 15 mg/mL (40.83 mM), Sonication and heating to 60℃ are recommended.

References and Literature

1. Chen DS, et al. Combinatorial synthesis of pyrazoloquinoline and pyrazoloacridine derivatives with high regioselectivity. Comb Chem High Throughput Screen. 2013 Jun 28;16(7):550-61. 2. J S Sebolt, et al. Pyrazoloacridines, a new class of anticancer agents with selectivity against solid tumors in vitro. Cancer Res. 1987 Aug 15;47(16):4299-304. 3. A A Adjei, et al. Effect of pyrazoloacridine (NSC 366140) on DNA topoisomerases I and II. Clin Cancer Res. 1998 Mar;4(3):683-91. 4. Reid JM, et al. The metabolism of pyrazoloacridine (NSC 366140) by cytochromes p450 and flavin monooxygenase in human liver microsomes. Clin Cancer Res. 2004 Feb 15;10(4):1471-80.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Clinical Compound Library Drug Repurposing Compound Library Anti-Cancer Drug Library Inhibitor Library Anti-Cancer Active Compound Library Clinical Compound Library Human Metabolite Library ReFRAME Related Library Bioactive Compound Library DNA Damage & Repair Compound Library

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Pyrazoloacridine 99009-20-8 Apoptosis DNA Damage/DNA Repair Topoisomerase tumor Inhibitor leukemia inhibit solid PD-115934 PD115934 NSC 366140 carcinoma NSC-366140 PD 115,934 pancreatic PD 115934 myeloid NSC366140 inhibitor

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