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Protirelin Acetate

Protirelin Acetate
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Purity:96.17%
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Protirelin Acetate

Catalog No. TP1022Cas No. 120876-23-5
Protirelin Acetate (TRH Acetate) is a thyrotropin-releasing hormone, stimulating the release of thyrotropin and prolactin from the anterior pituitary.
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Pack SizePriceAvailabilityQuantity
5 mg$40In Stock
10 mg$67In Stock
25 mg$81In Stock
50 mg$97In Stock
100 mg$157In Stock
500 mg$392Backorder
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Product Introduction

Bioactivity
Description
Protirelin Acetate (TRH Acetate) is a thyrotropin-releasing hormone, stimulating the release of thyrotropin and prolactin from the anterior pituitary.
In vivo
Protirelin (TRH) is an ancient neuropeptide that emerged before the divergence of protostomes and deuterostomes, possibly playing a role in regulating postembryonic growth and reproduction[1]. This study explores Protirelin's impact on body temperature, administering intraperitoneal doses of 1, 5, 10, and 20 mg/kg to male Wistar rats weighing 200-250 g. The findings reveal a dose-dependent, temporary increase in body temperature following Protirelin administration. However, thyroidectomized rats injected with 20 mg/kg of Protirelin did not experience a temperature rise, unlike their sham-operated counterparts. These observations indicate that thyroid hormone release may contribute to Protirelin's hyperthermic effect[2].
AliasTSH-RF Acetate, TRH Acetate, TRF Acetate
Chemical Properties
Molecular Weight452.46
FormulaC16H22N6O4.3/2C2H4O2
Cas No.120876-23-5
Storage & Solubility Information
Storagestore at low temperature,keep away from moisture Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Solubility Information
H2O: 50 mg/mL (110.51 mM)
Solution Preparation Table
H2O
1mg5mg10mg50mg
1 mM2.2101 mL11.0507 mL22.1014 mL110.5070 mL
5 mM0.4420 mL2.2101 mL4.4203 mL22.1014 mL
10 mM0.2210 mL1.1051 mL2.2101 mL11.0507 mL
20 mM0.1105 mL0.5525 mL1.1051 mL5.5254 mL
50 mM0.0442 mL0.2210 mL0.4420 mL2.2101 mL
100 mM0.0221 mL0.1105 mL0.2210 mL1.1051 mL

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Preparation method for in vivo formula: Take 50 μLDMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μLTween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify.
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