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Protirelin Acetate

Catalog No. TP1022 CAS 120876-23-5

Synonyms: 醋酸普罗瑞林, TSH-RF Acetate, TRH Acetate, TRF Acetate

Protirelin Acetate is a thyrotropin-releasing hormone, stimulating the release of thyrotropin and prolactin from the anterior pituitary.

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Protirelin Acetate, CAS 120876-23-5

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

Protirelin Acetate is a thyrotropin-releasing hormone, stimulating the release of thyrotropin and prolactin from the anterior pituitary.

In vivo

Protirelin (TRH) is an evolutionarily ancient neuropeptide, having its origin before the divergence of protostomes and deuterostomes that may ancestrally have been involved in the control of postembryonic growth and reproduction[1]. The effect of the thyrotropin-releasing hormone (Protirelin, TRH), one of the hypothalamic releasing hormones, on body temperature is investigated in the rat. Protirelin, in doses of 1, 5, 10 and 20 mg/kg, is injected intraperitoneally to male Wistar rats weighing 200-250 g. Protirelin causes a temporary rise in body temperature dose-dependently. The thyroidectomized rats injected 20 mg/kg of Protirelin which induces a significant hyperthermia in the sham-operated animals, fail to show a rise in body temperature. The present results suggest that a release of thyroid hormone might participate in the hyperthermic action of Protirelin[2].

Synonyms	醋酸普罗瑞林, TSH-RF Acetate, TRH Acetate, TRF Acetate
Molecular Weight	904.936
Formula	C38H56N12O14
CAS No.	120876-23-5

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

H2O: 50 mg/mL (110.51 mM), Need ultrasonic

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Van Sinay E, et al. Evolutionarily conserved TRH neuropeptide pathway regulates growth in Caenorhabditis elegans. Proc Natl Acad Sci U S A. 2017 May 16;114(20):E4065-E4074.

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Keywords

Protirelin Acetate 120876-23-5 代谢内分泌与激素 Endogenous Metabolite Thyroid hormone receptor(THR) TRH Acetate inhibit THR TRF Acetate Protirelin TRH Thyroid Hormone Receptor TSH-RF Acetate Inhibitor inhibitor

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