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Pramocaine hydrochloride

Catalog No. T0460 CAS 637-58-1

Synonyms: Pramoxine hydrochloride, Pramoxine HCl

Pramocaine hydrochloride (Pramoxine HCl), a topical anesthetic, is served as an antipruritic.

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Pramocaine hydrochloride Chemical Structure

Pramocaine hydrochloride, CAS 637-58-1

Pack Size	Availability	Price/USD
500 mg	In stock	$ 41.00
1 g	In stock	$ 48.00
1 mL * 10 mM (in DMSO)	In stock	$ 45.00

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Purity: 99.57%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Pramocaine hydrochloride (Pramoxine HCl), a topical anesthetic, is served as an antipruritic.
In vitro	When administered to canines exhibiting dyspnea (breathing difficulty) and tremors, Pramoxine elicited specific changes in skin temperature at which the activation and suppression of panting and shivering occur. These changes are thought to be mediated by peripheral nerves that control the terminal mechanisms of thermoregulation. In studies on guinea pig ileum, Pramoxine (1.7 mM) demonstrated a lesser reduction in response to Substance P compared to its effects on responses to acetylcholine, BaCl2, and histamine. Pramoxine has been identified as having anesthetic inhibitory potency, with a pKa of 6.4 in guinea pig ileum.
In vivo	Pramoxine is frequently used in conjunction with Hydrocortisone, Colloidal oatmeal, Menthol, and Petrolatum.

Synonyms	Pramoxine hydrochloride, Pramoxine HCl
Molecular Weight	329.86
Formula	C17H27NO3·HCl
CAS No.	637-58-1

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 45 mg/mL (136.42 mM)

References and Literature

1. Rosenkrantz W, et al. Clin Tech Small Anim Pract, 2006, 21(3), 106-116. 2. Bury RW, et al. J Pharmacol Exp Ther, 1976, 197(3), 633-640. 3. HELMENDACH RH, et al. Am J Physiol, 1962, 202, 1237-1240.

Related compound libraries

This product is contained In the following compound libraries：

Drug Repurposing Compound Library Anti-Cancer Drug Library Membrane Protein-targeted Compound Library Anti-Cancer Approved Drug Library Bioactive Compounds Library Max Drug-Fragment Library FDA-Approved & Pharmacopeia Drug Library Approved Drug Library Ion Channel Inhibitor Library FDA-Approved Drug Library

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Pramocaine hydrochloride 637-58-1 Membrane transporter/Ion channel Sodium Channel Pramocaine Pramoxine Pramoxine hydrochloride Pramoxine Hydrochloride Inhibitor inhibit Pramocaine Hydrochloride Pramoxine HCl inhibitor

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