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Oxybenzone

Catalog No. T0499   CAS 131-57-7
Synonyms: Benzophenone 3, Eusolex 4360, Escalol 567, KAHSCREEN BZ-3

Oxybenzone is an organic compound used in sunscreens. It is a derivative of benzophenone.

Oxybenzone, CAS 131-57-7
Pack Size Availability Price/USD Quantity
100 mg In stock 28.00
500 mg In stock 50.00
1 mL * 10 mM (in DMSO) In stock 50.00
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Purity 99.92%
Biological Description
Chemical Properties
Storage & Solubility Information
Description Oxybenzone is an organic compound used in sunscreens. It is a derivative of benzophenone.
Targets&IC50 Others
In vitro A dose-dependent inhibition of PGE2-production is found in the HEPM cell culture following oxybenzone exposure[1]. Benzophenones, including oxybenzone(BP-3) are documented mutagens that increase the rate of damage to DNA, especially when exposed to sunlight. It either can act directly as genotoxicants or become genotoxicants by bioactivation via cytochrome P450 enzymes. Oxybenzone can generate reactive oxygen species, which are potential mutagens, when applied topically to the skin followed by UV light exposure[2].
In vivo In mice studies, oxybenzone(BP-3) exposure significantly affects fecundity, as well as inducing unexplained mortality in lactating mothers. Studies in both mice and rats demonstrate that generational exposure to oxybenzone(BP-3) reduces body weight, increases liver ([50 %) and kidney weights, induces a 30 % increase in prostate weight, a reduction in immunocompetence, and significantly increases uterine weight in juveniles. In mammals, oxybenzone(BP-3) is renowned for having estrogenic and anti-androgenic activities, causing activation of estrogen receptor proteins and inhibition of androgen receptors[2].
Cell Research
Cells are grown at 37℃ with 100% humidity and 10% CO2. Prior to analyses, cells are subcultured onto 24-well plates and allowed to become 70-90% confluent. On day 1 of the experiment, cells are washed three times with serum-free media containing 0.5% bovine serum albumin (BSA), followed by replacement with the same media that also contained 1 ng/ml of IL-1β with or without oxybenzone. After an exposure time of 24 h, the media are removed, the pH adjusted to 3.5 with HCl, and finally assayed for PGE2-production. (Only for Reference)
Cell lines: Human embryo palatal mesenchyme cells
Synonyms Benzophenone 3 , Eusolex 4360 , Escalol 567 , KAHSCREEN BZ-3
Purity 99.92%
Molecular Weight 228.24
Formula C14H12O3
CAS No. 131-57-7

Storage

0-4℃ for short term (days to weeks), or -20℃ for long term (months).

Solubility Information

DMSO: 197.2 mM

( < 1 mg/ml refers to the product slightly soluble or insoluble )

Citations

References and Literature
1. Jannesson L, et al. J Clin Periodontol. 2004, 31(2):91-4. 2. Downs CA, et al. Arch Environ Contam Toxicol. 2016, 70(2):265-88.

Related compound libraries

This product is contained In the following compound libraries:
FDA Approved & Pharmacopeial Drug Library

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