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Endocrinology/Hormones RAAS Olmesartan

Olmesartan

Catalog No. T5964   CAS 144689-24-7
Synonyms: RNH 6270, CS 088, RNH 6270, CS 088

Olmesartan is an Angiotensin II Type I receptor antagonist. Olmesartan is the active form of the antihypertensive drug olmesartan medoxomil,and has antihypertensive activity.

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Olmesartan, CAS 144689-24-7
Pack Size Availability Price/USD Quantity
100 mg In stock 58.00
500 mg In stock 171.00
1 mL * 10 mM (in DMSO) In stock 30.00
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Purity 91.89%
Biological Description
Chemical Properties
Storage & Solubility Information
Description Olmesartan is an Angiotensin II Type I receptor antagonist. Olmesartan is the active form of the antihypertensive drug olmesartan medoxomil,and has antihypertensive activity.
Targets&IC50 angiotensin II receptor
Animal Research
In a randomized, double-blind, multicenter, controlled trial, Assigned 4447 patients with type 2 diabetes to receive olmesartan (at a dose of 40 mg once daily) or placebo for a median of 3.2 years.Additional antihypertensive drugs (except angiotensin-converting-enzyme inhibitors or ARBs) were used as needed to lower blood pressure to less than 130/80 mm Hg. The primary outcome was the time to the first onset of microalbuminuria.The times to the onset of renal and cardiovascular events were analyzed as secondary end points[1].
Synonyms RNH 6270 , CS 088 , RNH 6270 , CS 088
Purity 91.89%
Molecular Weight 446.5
Formula C24H26N6O3
CAS No. 144689-24-7

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 6 months

Solubility Information

DMSO: 55 mg/mL (123.18 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

Citations

References and Literature
1. Haller H , Ito S , Izzo J L , et al. Olmesartan for the Delay or Prevention of Microalbuminuria in Type 2 Diabetes[J]. New England Journal of Medicine, 2011, 364(10):907-917. 2. Omboni S, Volpe M.Management of arterial hypertension with angiotensin receptor blockers: Current evidence and the role of olmesartan[1].Cardiovasc Ther. 2018 Dec;36(6):e12471.

Related compound libraries

This product is contained In the following compound libraries:
Approved Drug Library Bioactive Compound Library Inhibitor Library Clinical Compound Library Anti-Diabetic Compound Library Endocrinology-Hormone Compound Library FDA-Approved Drug Library GPCR Compound Library Anti-Obesity Compound Library Drug Repurposing Compound Library Drug-induced Liver Injury (DILI) Compound Library NMPA-Approved Drug Library FDA-Approved & Pharmacopeia Drug Library

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