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Oleanonic acid

Catalog No. T3321 CAS 17990-42-0

Synonyms: 3-Oxooleanolic acid, 3-Oxoolean-12-en-28-oic Acid, Oleanonic Acid, 3-Ketooleanolic Acid

Oleanonic acid (3-Ketooleanolic Acid) is relatively non-toxic, hepatoprotective, and exhibits antitumor and andantiviral properties.

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Oleanonic acid, CAS 17990-42-0

Pack Size	Availability	Price/USD	Quantity
50 mg	In stock	$ 50.00
1 mL * 10 mM (in DMSO)	In stock	$ 50.00

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Purity: 99.22%

Purity: 95.58%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Oleanonic acid (3-Ketooleanolic Acid) is relatively non-toxic, hepatoprotective, and exhibits antitumor and andantiviral properties.
Targets&IC50	Macrophages:57.4 mM(EC50), PBMC:22.7 mM (EC50), Monocyte:24.6 mM (EC50)
Kinase Assay	Cerebral cortices from male Sprague-Dawley rats (200-300 g) are homogenized in 9 volumes of ice-cold 0.32mol/Lsucrose by nine strokes with a Teflon/glass homogenizer at 500 rpm. The homogenate is centrifuged for 10 min at 1×103 g, and the supernatant is recentrifuged at 1×104 g for 20 min at 4°C. The pellet is suspended in assay buffer (118 mM NaCl/4.7 mM KCl/1.2 mM MgSO4/5 mM NaHCO3/20 mM Hepes/1.2 mM KH2PO4/2.5 mM CaCl2/11 mM glucose, pH 7.4) and incubated at 23°C for 20 min prior to final centrifugation at 1×103 g for 20 min at 4°C. The pellet is resuspended in assay buffer (70 mL per gram of original tissue). Binding of [3H]MK-801 is measured by incubating 750 μL duplicate aliquots of this crude membrane suspension (=0.75 mg of protein) with 100 μL of buffer containing displacer or of buffer alone (total binding), 100 μL of 50 nM [3H]MK-801, and 50 μL of buffer for 60 min at 23°C. Nonspecific binding is defined by 100 μM (final concentration) unlabeled MK-801.
Source	Natural Products > Oleaceae > Ligustrum

Synonyms	3-Oxooleanolic acid, 3-Oxoolean-12-en-28-oic Acid, Oleanonic Acid, 3-Ketooleanolic Acid
Molecular Weight	454.68
Formula	C30H46O3
CAS No.	17990-42-0

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 100 mg/mL (219.93 mM), Sonication is recommended.

H2O: < 0.1 mg/mL (insoluble)

References and Literature

1. Liu J. Journal of Ethnopharmacology. 1995, 49 (2): 57–68.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Active Compound Library Traditional Chinese Medicine Monomer Library Chinese Pharmacopoeia Natural Product Library Natural Product Library NO PAINS Compound Library The Yao nationality medicine Library Anti-COVID-19 Traditional Chinese Medicine Compound Library Selected Plant-Sourced Compound Library Anti-Tumor Natural Product Library Anti-Cancer Compound Library

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Keywords

Oleanonic acid 17990-42-0 Microbiology/Virology Proteases/Proteasome HIV Protease 3-Oxooleanolic acid 3-Oxoolean-12-en-28-oic Acid Oleanonic Acid HIV Human immunodeficiency virus inhibit Inhibitor 3-Ketooleanolic Acid inhibitor

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