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Salicylanilide

Catalog No. T0753   CAS 87-17-2
Synonyms: WR10019, 2-Hydroxybenzanilide

Salicylanilide (2-Hydroxybenzanilide)s are a group of compounds with antiviral potency, antibacterial and antifungal activities.

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Salicylanilide Chemical Structure
Salicylanilide, CAS 87-17-2
Pack Size Availability Price/USD Quantity
50 mg In stock $ 33.00
100 mg In stock $ 47.00
200 mg In stock $ 60.00
500 mg In stock $ 95.00
1 mL * 10 mM (in DMSO) In stock $ 50.00
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Purity: 99.68%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Salicylanilide (2-Hydroxybenzanilide)s are a group of compounds with antiviral potency, antibacterial and antifungal activities.
In vitro Some salicylanilides and salicylamides could inhibit HIV virus by targeting of HIV-1 integrase or reverse transcriptase. Hepatitis C virus could be potentially afflicted by salicylanilides on the level of two enzymes – NS3 protease and NS5B RNA polymerase. Nitazoxanide is a nitrothiazole derivative of salicylamide useful for the treatment of protozoal and bacterial infections with an extended range of antiviral activity and innovative mechanism of action, especially against hepatitis and influenza viruses or rotaviruses. Nitazoxanide, its metabolite tizoxanide and their derivatives are a very promising stream in the development of new antiviral compounds.[1] Salicylanilides is potential virulence inhibitors attributable to a blockade of the type III secretion pathway. Many salicylanilide ester derivatives have been demonstrated an effective and promising treatment against pathogenic fungi and bacteria (especially against Gram-positive, tuberculous and atypical mycobacterial strains), including strains such as methicillinresistant Staphylococcus aureus and isoniazid-resistant mycobacteria which are resistant to one or more clinically used drugs.[2]
Synonyms WR10019, 2-Hydroxybenzanilide
Molecular Weight 213.23
Formula C13H11NO2
CAS No. 87-17-2

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: < 1 mg/mL (insoluble or slightly soluble)

Ethanol: 15 mg/mL (70.3 mM)

DMSO: 40 mg/mL (187.6 mM)

TargetMolReferences and Literature

1. Krátký M, et al. Mini Rev Med Chem, 2011, 11(11), 956-967 2. Krátký M, et al. Curr Pharm Des, 2011, 17(32), 3494-3505

Related compound libraries

This product is contained In the following compound libraries:
Anti-Fungal Compound Library Anti-Viral Compound Library Anti-Bacterial Compound Library Anti-COVID-19 Compound Library Anti-Metabolism Disease Compound Library Bioactive Compounds Library Max FDA-Approved & Pharmacopeia Drug Library Bioactive Compound Library Approved Drug Library Anti-Infection Compound Library

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Keywords

Salicylanilide 87-17-2 Microbiology/Virology Proteases/Proteasome HIV Protease Reverse Transcriptase WR 10019 HIV Human immunodeficiency virus HIV Integrase WR10019 inhibit Inhibitor WR-10019 2-Hydroxybenzanilide inhibitor

 

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