store at low temperature
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Novobiocin is an orally active and potent antibiotic.Novobiocin is a DNA gyrase inhibitor and heat shock protein 90 (Hsp90) antagonist with inhibitory effects on gyrase and Hsp90. Novobiocin has anti-positive activity and can be used to study highly resistant pneumococcal infections.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 30.00 | |
5 mg | In stock | $ 58.00 | |
10 mg | In stock | $ 87.00 | |
25 mg | In stock | $ 157.00 | |
50 mg | In stock | $ 236.00 | |
100 mg | In stock | $ 360.00 | |
500 mg | In stock | $ 790.00 |
Description | Novobiocin is an orally active and potent antibiotic.Novobiocin is a DNA gyrase inhibitor and heat shock protein 90 (Hsp90) antagonist with inhibitory effects on gyrase and Hsp90. Novobiocin has anti-positive activity and can be used to study highly resistant pneumococcal infections. |
In vitro |
Novobiocin (1 mM) competitively hinders the binding of ATP to gyrase B, disrupting nucleotide binding, and impairs the interaction between the co-chaperones Hsc70 and p23 with Hsp90.[1] Novobiocin (200 µM; 24 h) results in the inhibition of the repair rate of DNA interstrand cross-links induced by both cisplatin (cis-DDP) and BCNU. This is accompanied by a corresponding reduction in the clonogenic survival of human glioblastoma multiforme cells.[2] Novobiocin (0.3 mM; 48 hours) triggers caspase-3/7 enzyme-dependent apoptosis assays, resulting in an approximate three- to fivefold increase in the number of apoptotic cells in K562, HL60, and Mutz-2.[5] |
In vivo | Novobiocin (25, 50, 100, 200 mg/kg; s.c.; 4 times at 1, 5, 24, and 48 h after infection; Adult female Swiss mice (30g) with sepsis induced by the penicillin-susceptible strain (AR33118)) shows anti-infection activity in mice infected with amoxicillin-resistant Streptococcus pneumoniae.[3] |
Synonyms | U-6391, U 6391, U6391, Cathomycin, Albamycin |
Molecular Weight | 612.62 |
Formula | C31H36N2O11 |
CAS No. | 303-81-1 |
store at low temperature
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: Soluble
You can also refer to dose conversion for different animals. More
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
Novobiocin 303-81-1 Apoptosis Cytoskeletal Signaling DNA Damage/DNA Repair Metabolism Microbiology/Virology Virus Protease HSP Antibacterial Antibiotic DNA gyrase U-6391 U 6391 U6391 Cathomycin Albamycin inhibitor inhibit