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Notoginsenoside Ft1

Catalog No. T5761 CAS 155683-00-4

Notoginsenoside Ft1 is a saponin originally isolated from P. notoginseng with diverse biological activities

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Notoginsenoside Ft1, CAS 155683-00-4

Pack Size	Availability	Price/USD
2 mg	In stock	$ 50.00
5 mg	In stock	$ 77.00
10 mg	In stock	$ 98.00
25 mg	In stock	$ 148.00
50 mg	In stock	$ 222.00
1 mL * 10 mM (in DMSO)	In stock	$ 89.00

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Purity: 99.75%

Purity: 98.95%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Notoginsenoside Ft1 is a saponin originally isolated from P. notoginseng with diverse biological activities
In vitro	Notoginsenoside Ft1 (Ft1) is a novel stimulator of angiogenesis. Ft1 induces proliferation, migration, and tube formation in cultured human umbilical vein endothelial cells (HUVECs). Ft1 increases translocalization of hypoxia-inducible factor-1α (HIF-1α) from cytoplasm to nuclei, where it binds to the vascular endothelial growth factor (VEGF) promoter, increasing the expression of VEGF mRNA and the subsequent secretion of the growth factor. Ft1 induces the activation of PI3K/AKT and Raf/MEK/ERK signaling pathways. Pharmacological inhibition with LY294002, wortmanin or PD98059 reduces Ft1-induced angiogenesis, indicating the important role played by these pathways. In addition, Ft1 induces phosphorylation of the mammalian target of rapamycin (mTOR), and siRNA-mediated mTOR knockdown decreases tube formation, proliferation, transport of HIF-1α into nuclei and VEGF mRNA expression in response to Ft1[1].Among the saponins examined, Notoginsenoside Ft1(Ft1) was the most potent procoagulant and induced dose-dependent platelet aggregation. Ft1 reduced plasma coagulation indexes, decreased tail bleeding time and increased thrombogenesis. Moreover, it potentiated ADP-induced platelet aggregation and increased cytosolic Ca(2+) accumulation, effects that were attenuated by clopidogrel[2].
Kinase Assay	Platelet aggregation was analysed using a platelet aggregometer. Prothrombin time, activated partial thromboplastin time and thrombin time were measured using a blood coagulation analyser, which was further corroborated with bleeding time and thrombotic assays[2].
Source	Natural Products > Araliaceae > Panax

Molecular Weight	917.13
Formula	C47H80O17
CAS No.	155683-00-4

Storage

keep away from direct sunlight

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 25 mg/mL (27.26 mM)

References and Literature

1. Shen K , Ji L , Gong C , et al. Notoginsenoside Ft1 promotes angiogenesis via HIF-1α mediated VEGF secretion and the regulation of PI3K/AKT and Raf/MEK/ERK signaling pathways[J]. Biochemical Pharmacology, 2012, 84(6). 2. Gao B , Huang L , Liu H , et al. Platelet P2Y12 receptor involved in the hemostatic effect of notoginsenoside Ft1, a saponin isolated from Panax notoginseng[J]. British Journal of Pharmacology, 2013, 171(1):214-223.

Related compound libraries

This product is contained In the following compound libraries：

Traditional Chinese Medicine Monomer Library PBCRBS Traditional Chinese Medicine Compound Library Bioactive Compounds Library Max Terpene Natural Product Library Epigenetics Compound Library Natural Product Library Saccharide and Glycoside Natural Product Library Anti-Tumor Natural Product Library Selected Plant-Sourced Compound Library Chinese Pharmacopoeia Natural Product Library

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Keywords

Notoginsenoside Ft1 155683-00-4 Chromatin/Epigenetic Metabolism Others HIF/HIF Prolyl-Hydroxylase inhibit Notoginsenoside Ft 1 Inhibitor Notoginsenoside Ft-1 inhibitor

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