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Nortrachelogenin

Catalog No. TN4675   CAS 34444-37-6

Nortrachelogenin is a novel agent for prostate cancer therapy with ability to inhibit Akt membrane localization and activity as well as the activation of growth factor receptors, thereby efficiently synergizing with tumor necrosis factor-related apoptosis-inducing ligand (TRAIL), exposure.Nortrachelogenin has anti-inflammatory properties,it shows moderate inhibiting activities on NF- κB signaling pathway induced by TNF-α , with the IC50 value of 49.4 uM. Nortrachelogenin also shows anti-plasmodium activity of 14.50 dg/ml. (+ )-Nortrachelogenin shows effects on the central nervous system producing depression in rabbits, it is moderately active against HIV-1 in vitro. (-)-Nortrachelogenin exerts its antibacterial effect by disorganizing and perturbing the cytoplasmic membrane, it also can induce membrane disruption and caspase-dependent apoptosis.

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Nortrachelogenin, CAS 34444-37-6
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Purity: 98%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Nortrachelogenin is a novel agent for prostate cancer therapy with ability to inhibit Akt membrane localization and activity as well as the activation of growth factor receptors, thereby efficiently synergizing with tumor necrosis factor-related apoptosis-inducing ligand (TRAIL), exposure.Nortrachelogenin has anti-inflammatory properties,it shows moderate inhibiting activities on NF- κB signaling pathway induced by TNF-α , with the IC50 value of 49.4 uM. Nortrachelogenin also shows anti-plasmodium activity of 14.50 dg/ml. (+ )-Nortrachelogenin shows effects on the central nervous system producing depression in rabbits, it is moderately active against HIV-1 in vitro. (-)-Nortrachelogenin exerts its antibacterial effect by disorganizing and perturbing the cytoplasmic membrane, it also can induce membrane disruption and caspase-dependent apoptosis.
Molecular Weight 374.38
Formula C20H22O7
CAS No. 34444-37-6

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

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( < 1 mg/ml refers to the product slightly soluble or insoluble )

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Keywords

Nortrachelogenin 34444-37-6 G蛋白偶联受体 NF-Kb信号通路 PI3K/Akt/mTOR信号通路 蛋白酪氨酸激酶 蛋白酶体 凋亡 免疫与炎症 神经科学 微生物学 细胞骨架 COX Caspase Antifection Akt NF-κB NOS IL Receptor IGF-1R HIV Protease Prostaglandin Receptor ROS TNF Inhibitor inhibitor inhibit