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Neostigmine methyl sulfate

Catalog No. T1612 CAS 51-60-5

Synonyms: Normastigmin, Syntostigmin, Hodostin

Hodostin is a reversible inhibitor of acetylcholinesterase, can not cross the blood-brain barrier, used in the treatment of myasthenia gravis.

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Neostigmine methyl sulfate, CAS 51-60-5

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

Hodostin is a reversible inhibitor of acetylcholinesterase, can not cross the blood-brain barrier, used in the treatment of myasthenia gravis.

Synonyms	Normastigmin, Syntostigmin, Hodostin
Molecular Weight	334.39
Formula	C13H22N2O6S
CAS No.	51-60-5

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 200.4 mM

H2O: 200.4 mM

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Huang TH, et al. Yao Xue Xue Bao. 1982 Jul;17(7):534-9.

Dose Conversion

You can also refer to dose conversion for different animals. More

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

Note:

Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

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What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?
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What volume of a given 10 mM stock solution is required to make 20ml of a 50 μM solution?
Using the equation C1V1 = C2V2, where C1=10 mM, C2=50 μM, V2=20 ml and V1 is the unknown:
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Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed n the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Neostigmine methyl sulfate 51-60-5 Neuroscience AChE AChR Cholinesterase (ChE) Neostigmine methyl Normastigmin inhibit Syntostigmin Hodostin Inhibitor inhibitor

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.