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Microbiology/Virology Antibacterial Monensin sodium salt

Monensin sodium salt

Catalog No. T1033   CAS 22373-78-0
Synonyms: Monensin A sodium salt, Sodium Monensin

Monensin sodium is an antiprotozoal agent produced by Streptomyces cinnamonensis.Monensin sodium salt causes a marked enlargement of the MVBs and regulates exosome secretion

Monensin sodium salt, CAS 22373-78-0
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25 mg In stock 30.00
50 mg In stock 38.00
100 mg In stock 50.00
200 mg In Stock 67.00
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Purity 98.90%
Purity 98.00%
Purity 98.00%
Biological Description
Chemical Properties
Storage & Solubility Information
Description Monensin sodium is an antiprotozoal agent produced by Streptomyces cinnamonensis.Monensin sodium salt causes a marked enlargement of the MVBs and regulates exosome secretion
Targets&IC50 Others
In vitro Monensin sodium salt (Coban), isolated from Streptomyces cinnamonensis, is a well-known representative of naturally polyether ionophore antibiotics. Monensin is an ionophore related to the crown ethers with a preference to form complexes with monovalent cations such as: Li+, Na+, K+, Rb+, Ag+, and TI+. [1] Monensin A is able to transport these cations across lipid membranes of cells, playing an important role as an Na+/H+ antiporter. It blocks intracellular protein transport, and exhibits antibiotic, antimalarial, and other biological activities. [2] The antibacterial properties of monensin and its derivatives are a result of their ability to transport metal cations through cellular and subcellular membranes. [3]
In vivo LD50: Mice 335 mg/kg (i.g.) [4]; Rats 36.5 mg/kg (i.g.); Chickens 185 mg/kg (i.g.). [5]
Synonyms Monensin A sodium salt , Sodium Monensin
Purity 98.90%
Molecular Weight 692.85
Formula C36H61NaO11
CAS No. 22373-78-0

Storage

0-4℃ for short term (days to weeks), or -20℃ for long term (months).

Solubility Information

Ethanol: 69.3 mg/mL (100 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

Citations

References and Literature
1. Pinkerton M, et al. J Mol Biol, 1970, 49(3), 533-546. 2. Mollenhauer HH, et al. Biochim Biophys Acta, 1990, 1031(2), 225-246. 3. Huczynski A, et al. Bioorg Med Chem Lett, 2008, 18(8), 2585-2589.

Related compound libraries

This product is contained In the following compound libraries:
Approved Drug Library Bioactive Compound Library Inhibitor Library Natural Compound Library for HTS Anti-infection Compound Library Immunology/Inflammation Compound Library Antibiotics Library

Related Products

Related compounds with same targets
Monensin sodium salt Bafilomycin A1 TH1020 Mecillinam Tacrolimus hydrate Ligustilide A Thiobarbituric acid Thermopsine

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