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Mometasone furoate

Catalog No. T1531 CAS 83919-23-7

Synonyms: Sch32088

Mometasone furoate (Sch32088) is a pregnadienediol derivative ANTI-ALLERGIC AGENT and ANTI-INFLAMMATORY AGENT that is used in the management of ASTHMA and ALLERGIC RHINITIS. It is also used as a topical treatment for skin disorders.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

Mometasone furoate, CAS 83919-23-7

Pack Size	Availability	Price/USD
25 mg	In stock	$ 39.00
50 mg	In stock	$ 48.00
100 mg	In stock	$ 88.00
200 mg	In stock	$ 108.00
1 mL * 10 mM (in DMSO)	In stock	$ 48.00

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Purity: 99.56%

Purity: 99.43%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Mometasone furoate (Sch32088) is a pregnadienediol derivative ANTI-ALLERGIC AGENT and ANTI-INFLAMMATORY AGENT that is used in the management of ASTHMA and ALLERGIC RHINITIS. It is also used as a topical treatment for skin disorders.
In vitro	Both 0.02% Mometasone furoate and 0.1% Fluticasone propionate significantly suppress the increase in antigen-induced nasal rubbing even six hours after topical application, demonstrating their lasting effects. Mometasone furoate reduces nasal rubbing in rats and, at the highest tested dose in mice (3mg/kg), inhibits the increased sensitivity to aerosolized acetylcholine. The compound dose-dependently suppresses the elevation of eosinophil counts in the bronchoalveolar lavage fluid and lung tissue of mice challenged with sensitizing ovalbumin. Furthermore, a dosage of 33 mg/kg Mometasone furoate lowers the percentage of CD44+ T helper cells (activated/memory cells) to levels observed in mice not challenged with sensitizing ovalbumin, indicating its immunomodulatory potential.
In vivo	Mometasone furoate effectively inhibits the production of cytokines, including interleukin (IL)-4, IL-5, and interferon-γ, in human CD4+ T cells stimulated by anti-CD3. It also efficiently suppresses the activation of Th cells, including type 2 helper T (Th2) cells, in draining lymph nodes, leading to the suppression of the IgE response.

Synonyms	Sch32088
Molecular Weight	521.43
Formula	C27H30Cl2O6
CAS No.	83919-23-7

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 6 mg/mL (11.5 mM)

Ethanol: < 1 mg/mL (insoluble or slightly soluble)

References and Literature

1. Magari M, et al. Immunopharmacol Immunotoxicol,2006, 28(3), 491-500. 2. Tsumuro T, et al. Eur J Pharmacol,2005, 524(1-3), 155-158. 3. Wyss D, et al. Br J Pharmacol,2007, 152(1), 83-90. 4. Sugimoto Y, et al. Pharmacology,2000, 61(2), 91-95. 5. Chapman RW, et al. Arzneimittelforschung,1998, 48(4), 384-391.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Clinical Compound Library Anti-Cancer Drug Library Anti-Cancer Approved Drug Library Drug Repurposing Compound Library EMA Approved Drug Library Anti-Cancer Compound Library Approved Drug Library Human Metabolite Library Anti-Fibrosis Compound Library Anti-Aging Compound Library

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Mometasone furoate 83919-23-7 Endocrinology/Hormones Glucocorticoid Receptor Inhibitor eczema hay fever inhibit skin corticosteroid Anti-inflammatory Sch 32088 Sch-32088 Mometasone Furoate asthma steroid Sch32088 inhibitor

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