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Membrane transporter/Ion channel Calcium Channel Mibefradil dihydrochloride

Mibefradil dihydrochloride

Catalog No. T12032   CAS 116666-63-8
Synonyms: Ro 40-5967 (dihydrochloride)

Mibefradil dihydrochloride is an blocker of calcium channel with moderate selectivity for T-type Ca2+ channels (T-type and L-type currents with IC50s of 2.7 μM and 18.6 μM, respectively).

Mibefradil dihydrochloride, CAS 116666-63-8
Pack Size Availability Price/USD Quantity
5 mg In stock 87.00
10 mg In stock 142.00
50 mg In stock 611.00
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Purity 99.45%
Biological Description
Chemical Properties
Storage & Solubility Information
Description Mibefradil dihydrochloride is an blocker of calcium channel with moderate selectivity for T-type Ca2+ channels (T-type and L-type currents with IC50s of 2.7 μM and 18.6 μM, respectively).
Targets&IC50 T-type calcium channel ,   L-type calcium channel
In vivo Compared with the saline-treated group, rats receiving Mibefradil or Ethosuximide show significant lower CaV3.2 expression in the spinal cord and DRG.
Cell Research
Human Orai1-3 cDNAs in tetracycline-regulated pcDNA4/TO vectors were transfected into HEK293 T-REx cells with stromal interaction molecule 1 (STIM1) stable expression. The Orai currents were recorded by whole-cell and excised-membrane patch clamp. Ca2+ influx or release was measured by Fura-PE3/AM. Cell growth and death were monitored by WST-1, LDH assays and flow cytometry[3].
Cell lines:
Synonyms Ro 40-5967 (dihydrochloride)
Purity 99.45%
Molecular Weight 568.55
Formula C29H40Cl2FN3O3
CAS No. 116666-63-8

Storage

0-4℃ for short term (days to weeks), or -20℃ for long term (months).

Solubility Information

H2O: 122 mg/mL (214.58mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

Citations

References and Literature
1. Brain KL, et al. The sources and sequestration of Ca(2+) contributing to neuroeffector Ca(2+) transients in the mouse vas deferens. J Physiol. 2003 Dec 1;553(Pt 2):627-35. 2. Yu YF, et al. Protection of the cochlear hair cells in adult C57BL/6J mice by T-type calcium channel blockers. Exp Ther Med. 2016 Mar;11(3):1039-1044. 3. Li P , Rubaiy H N , Gui‐Lan Chen, et al. Mibefradil, a T‐type Ca2+ channel blocker also blocks Orai channels by action at the extracellular surface[J]. British Journal of Pharmacology, 2019, 176. 4. Shiue SJ, et al. Chronic intrathecal infusion of T-type calcium channel blockers attenuates CaV3.2 upregulation in nerve-ligated rats. Acta Anaesthesiol Taiwan. 2016 Oct 17. pii: S1875-4597(16)30071-6.

Related compound libraries

This product is contained In the following compound libraries:
Inhibitor Library Ion Channel Inhibitor Library Calcium Antagonists Library

Related Products

Related compounds with same targets
MDK-4025 Mibefradil dihydrochloride 6-Methoxyluteolin Nicardipine Trimethadione Cytochalasin D Ginsenoside-Rf Gomisin J

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