Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Loxapine succinate (Loxapac), a D2DR and D4DR inhibitor, is utilized in schizophrenia.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
50 mg | In stock | $ 33.00 | |
100 mg | In stock | $ 47.00 | |
200 mg | In stock | $ 76.00 | |
500 mg | In stock | $ 167.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 52.00 |
Description | Loxapine succinate (Loxapac), a D2DR and D4DR inhibitor, is utilized in schizophrenia. |
Targets&IC50 | D2 receptor (human):24 nM(Ki), 5-HT2 (human):6.2 nM(Ki), 5-HT2 (bovine):6.6 nM(Ki), 5-HT2 (bovine):6.8 nM(Ki), D4 receptor (human):7.5 nM(Ki) |
In vitro | In rats, subcutaneous injection of Loxapine (0.3 mg/kg) induces general stiffness. In the rat brain, administering Loxapine (5 mg/kg) does not alter dopamine receptor density, but it reduces serotonin receptor density. |
In vivo | Loxapine effectively facilitates the binding of [3H]ketanserin to 5-HT2 receptors in both the human frontal cortex (ki=6.2 nM) and the bovine frontal cortex (ki=6.6 nM). Additionally, in LPS-activated mixed glial cells, loxapine at concentrations of 0.2 μM, 2 μM, and 20 μM, successfully reduces the secretion of IL-1β and IL-2. |
Synonyms | Daxolin, Loxapac, Cloxazepin, Loxapine succinate salt |
Molecular Weight | 445.9 |
Formula | C22H24ClN3O5 |
CAS No. | 27833-64-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Ethanol: 2 mg/mL (4.48 mM)
DMSO: 82 mg/mL (183.9 mM)
You can also refer to dose conversion for different animals. More
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