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Lotilaner

Name: Lotilaner
Brand: TargetMol
SKU: T15775
Price: 37 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T15775 Copy Product Info

Purity: 99.56%

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Lotilaner is an anthelmintic agent and a non-competitive GABA_A receptor antagonist with an IC₅₀ value of 23.84 nM for Drosophila GABA receptors. Lotilaner selectively acts on the nervous system of invertebrates to exert its anthelmintic effect and exhibits no significant affinity for mammalian GABA_A receptors.

Cas No. 1369852-71-0

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Pack Size	Price	USA Stock	Global Stock
1 mg	$37	In Stock	In Stock
2 mg	$53	In Stock	In Stock
5 mg	$86	In Stock	In Stock
10 mg	$147	In Stock	In Stock
25 mg	$353	In Stock	In Stock
50 mg	$579	In Stock	In Stock
100 mg	$928	-	In Stock
200 mg	$1,250	-	In Stock
1 mL x 10 mM (in DMSO)	$113	In Stock	In Stock

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:99.56%

Appearance:Solid

Color:White

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	Lotilaner is an anthelmintic agent and a non-competitive GABA_A receptor antagonist with an IC₅₀ value of 23.84 nM for Drosophila GABA receptors. Lotilaner selectively acts on the nervous system of invertebrates to exert its anthelmintic effect and exhibits no significant affinity for mammalian GABA_A receptors.
Targets & IC50	GABA:23.84 nM(DmS), GABA:36.79 nM(Rm), GABA:38.25 nM(DmR2), GABA:52.40 nM(Ls-GABA1)
In vitro	Methods: African clawed frog oocytes were injected with human (Hsa) and canine (Clu) GABAA receptor subunit cRNA. Lotilaner (0, 30, 100, 300 nM and 1, 3, 10, 30 μM) was added at each concentration for 60 seconds pre-incubation, followed by co-application with GABA at EC10 concentration for 10 seconds. Bipolar voltage-clamp recordings measured currents, and the half-maximal inhibitory concentration (IC50) was calculated. Results: For all 11 GABARs tested, Lotilaner exhibited IC50 values >30 μM, indicating negligible inhibition. [1]

Chemical Properties

Molecular Weight	596.76
Formula	C₂₀H₁₄Cl₃F₆N₃O₃S
Cas No.	1369852-71-0
Smiles	Cc1cc(sc1C(=O)NCC(=O)NCC(F)(F)F)C1=NO[C@@](C1)(c1cc(Cl)c(Cl)c(Cl)c1)C(F)(F)F
Relative Density.	1.66 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 166.67 mg/mL (279.29 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (3.35 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.6757 mL	8.3786 mL	16.7572 mL	83.7858 mL
5 mM	0.3351 mL	1.6757 mL	3.3514 mL	16.7572 mL
10 mM	0.1676 mL	0.8379 mL	1.6757 mL	8.3786 mL
20 mM	0.0838 mL	0.4189 mL	0.8379 mL	4.1893 mL
50 mM	0.0335 mL	0.1676 mL	0.3351 mL	1.6757 mL
100 mM	0.0168 mL	0.0838 mL	0.1676 mL	0.8379 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.