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Licoricidin

Catalog No. TN1867   CAS 30508-27-1

Licoricidin, is a potent anti-metastatic agent, which can markedly inhibit the metastatic and invasive capacity of malignant prostate cancer cells.

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Licoricidin Chemical Structure
Licoricidin, CAS 30508-27-1
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Biological Description
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Description Licoricidin, is a potent anti-metastatic agent, which can markedly inhibit the metastatic and invasive capacity of malignant prostate cancer cells.
In vitro This study examined whether HEGU and Licoricidin inhibit metastasis using the 4T1 mammary cancer model. Both HEGU and Licoricidin treatment reduced pulmonary metastasis and the expression of CD45, CD31, HIF-1α±, iNOS, COX-2, and VEGF-A in tumor tissues. Additionally, a decrease in protein expression of VEGF-R2, VEGF-C, VEGF-R3, and LYVE-1 was noted in tumor tissues of Licoricidin-treated mice. Furthermore, the blood concentrations of MMP-9, ICAM-1, VCAM-1, and VEGF-A were decreased in HEGU-treated mice. In vitro 4T1 cell culture results showed that both HEGU and Licoricidin inhibited cell migration, MMP-9 secretion, and VCAM expression[1]
Source
Molecular Weight 424.53
Formula C26H32O5
CAS No. 30508-27-1

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

TargetMolReferences and Literature

1. Licoricidin, an Active Compound in the Hexane/Ethanol Extract of Glycyrrhiza uralensis, Inhibits Lung Metastasis of 4T1 Murine Mammary Carcinoma CellsInt J Mol Sci. 2016 Jun 14;17(6). pii: E934

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Keywords

Licoricidin 30508-27-1 Angiogenesis Immunology/Inflammation Proteases/Proteasome Tyrosine Kinase/Adaptors ROS MMP VEGFR inhibitor inhibit

 

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