Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Levonorgestrel (D-Norgestrel) is a Progestin and Progestin-containing Intrauterine Device. The physiologic effect of levonorgestrel is by means of Inhibit Ovum Fertilization.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
100 mg | In stock | $ 42.00 | |
200 mg | In stock | $ 47.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 46.00 |
Description | Levonorgestrel (D-Norgestrel) is a Progestin and Progestin-containing Intrauterine Device. The physiologic effect of levonorgestrel is by means of Inhibit Ovum Fertilization. |
In vitro | Levonorgestrel significantly upregulates mRNA expression of the gene encoding luteinizing hormone beta subunit (lhβ) in both male and female cockroaches, while downregulating mRNA expression of the gene encoding follicle-stimulating hormone beta subunit (fshβ). Furthermore, in long-clawed ground squirrels, Levonorgestrel decreases the mRNA expression of ovarian follicle-stimulating hormone receptor, luteinizing hormone receptor, ovarian estrogen receptor β, and progesterone receptor, as well as the mRNA expression of ERα and PR in the uterus. |
In vivo | Levonorgestrel elevates cyclic AMP levels in the veins and inhibits the activation of protein kinase C induced by PMA. It suppresses progesterone secretion in rat luteal cells, which is stimulated by oLH, dibutyryl-cAMP, and pregnenolone. Levonorgestrel also inhibits contractions induced by high potassium (K(+)) solutions or PMA in the presence and absence of extracellular calcium (Ca(2+)), effectuating endothelium-dependent relaxation through hindrance of calcium ion ingress and protein kinase C activation. Moreover, while the inhibitory effects of Levonorgestrel on estrogen-induced pituitary weight gain and hyperprolactinemia are attenuated by mifepristone, flunarizine does not block its effects. |
Synonyms | D-Norgestrel |
Molecular Weight | 312.45 |
Formula | C21H28O2 |
CAS No. | 797-63-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 31.3 mg/mL (100 mM)
You can also refer to dose conversion for different animals. More
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Levonorgestrel 797-63-7 Endocrinology/Hormones Others Estrogen/progestogen Receptor Progesterone Receptor NR3C3 Inhibitor inhibit D-Norgestrel inhibitor