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L-689560

Catalog No. T15684 CAS 139051-78-8

L-689560 is widely used as a radiolabeled ligand in binding studies and used to study the roles of NMDA receptors in normal neurological processes as well as in diseases. At the GluN1 glycine binding site, L-689560 is an effective N-methyl-D-aspartate (NMDA) receptor antagonist.

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L-689560, CAS 139051-78-8

Pack Size	Availability	Price/USD	Quantity
10 mg	4-5 weeks	$ 668.00
50 mg	4-5 weeks	$ 2,790.00

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Description	L-689560 is widely used as a radiolabeled ligand in binding studies and used to study the roles of NMDA receptors in normal neurological processes as well as in diseases. At the GluN1 glycine binding site, L-689560 is an effective N-methyl-D-aspartate (NMDA) receptor antagonist.
In vitro	L-689560 is an antagonist of 2-carboxytetrahydroquinoline [2].
In vivo	L-689560 blocks the glycine-induced increase of Akt phosphorylation in the MCAO model. L-689560 (1?mg/kg, ip) obviously decreases the neuroprotective effect of glycine after glycine receptors, and the channel activity of NMDA receptors (NMDARs) are suppressed [1].

Molecular Weight	380.23
Formula	C17H15Cl2N3O3
CAS No.	139051-78-8

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Juan Chen, et al. A non-ionotropic activity of NMDA receptors contributes to glycine-induced neuroprotection in cerebral ischemia-reperfusion injury. 15 June 2017 2. Kvist T, et al. Crystal structure and pharmacological characterization of a novel N-methyl-D-aspartate (NMDA) receptor antagonist at the GluN1 glycine binding site. J Biol Chem. 2013 Nov 15;288(46):33124-35.

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Keywords

L-689560 139051-78-8 Membrane transporter/Ion channel Neuroscience iGluR NMDAR inhibit neurological Ionotropic glutamate receptors NMDA glycine radiolabeled L 689560 Inhibitor ligand 2-carboxytetrahydroquinoline L689560 GluN1 inhibitor

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