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Irbesartan

Catalog No. T1615   CAS 138402-11-6
Synonyms: SR-47436, BMS-186295

Irbesartan is an Angiotensin 2 Receptor Blocker. The mechanism of action of irbesartan is as an Angiotensin 2 Receptor Antagonist.

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Irbesartan, CAS 138402-11-6
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Purity: 98%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Irbesartan is an Angiotensin 2 Receptor Blocker. The mechanism of action of irbesartan is as an Angiotensin 2 Receptor Antagonist.
Targets&IC50 AT1 receptor:1.3 nM
Synonyms SR-47436, BMS-186295
Molecular Weight 428.54
Formula C25H28N6O
CAS No. 138402-11-6

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 25 mg/mL (58.34 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Bernhart CA, et al. J Med Chem, 1993, 36(22), 3371-3380. 2. Kawano H, et al. Hypertension, 2000, 35, 273-279. 3. Schupp M, et al. Circulation, 2004, 109(17), 2054-2057. 4. Ruiz E, et al. Eur J Pharmacol, 2007, 567(3), 231-239. 5. Dalla Libera L, et al. Circulation, 2001, 103(17), 2195-2200.

Dose Conversion

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Molarity Calculator
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Molarity Calculator allows you to calculate the

  • Mass of a compound required to prepare a solution of known volume and concentration
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An example of a molarity calculation using the molarity calculator
What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?
Enter 197.13 into the Molecular Weight (MW) box
Enter 10 into the Concentration box and select the correct unit (millimolar)
Enter 10 into the Volume box and select the correct unit (milliliter)
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The answer of 19.713 mg appears in the Mass box

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Calculator the dilution required to prepare a stock solution

Calculate the dilution required to prepare a stock solution
The dilution calculator is a useful tool which allows you to calculate how to dilute a stock solution of known concentration. Enter C1, C2 & V2 to calculate V1.

See Example

An example of a dilution calculation using the Tocris dilution calculator
What volume of a given 10 mM stock solution is required to make 20ml of a 50 μM solution?
Using the equation C1V1 = C2V2, where C1=10 mM, C2=50 μM, V2=20 ml and V1 is the unknown:
Enter 10 into the Concentration (start) box and select the correct unit (millimolar)
Enter 50 into the Concentration (final) box and select the correct unit (micromolar)
Enter 20 into the Volume (final) box and select the correct unit (milliliter)
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The answer of 100 microliter (0.1 ml) appears in the Volume (start) box

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Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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Enter the chemical formula of a compound to calculate its molar mass and elemental composition

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Instructions to calculate molar mass (molecular weight) of a chemical compound:
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Definitions of molecular mass, molecular weight, molar mass and molar weight:
Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed n the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Irbesartan 138402-11-6 Apoptosis Endocrinology/Hormones RAAS SR-47436 inhibit BMS 186295 BMS186295 hypertensive renal injury SR 47436 Angiotensin Receptor blood vessels Ang II type 1 (AT1) receptor blocker (ARB) Inhibitor blood heart failure Th22 cells SR47436 diabetic kidney disease BMS-186295 chemotaxis inhibitor