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Incyclinide

Catalog No. T15574   CAS 15866-90-7
Synonyms: COL-3, CMT-3

Incyclinide (COL-3) is a matrix metalloproteinase (MMP) inhibitor. Thereby causing extracellular matrix degradation, tumor growth and invasion, and inhibiting angiogenesis, and metastasis.

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Incyclinide Chemical Structure
Incyclinide, CAS 15866-90-7
Pack Size Availability Price/USD Quantity
1 mg In stock $ 80.00
5 mg In stock $ 122.00
10 mg In stock $ 198.00
25 mg In stock $ 427.00
50 mg In stock $ 648.00
100 mg In stock $ 923.00
1 mL * 10 mM (in DMSO) In stock $ 97.00
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Purity: 97.81%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Incyclinide (COL-3) is a matrix metalloproteinase (MMP) inhibitor. Thereby causing extracellular matrix degradation, tumor growth and invasion, and inhibiting angiogenesis, and metastasis.
In vitro Incyclinide has been shown to experimentally suppress prostate cancer, colon adenocarcinoma, and melanoma invasiveness in cell culture. Adding incyclinide at final concentrations of 5 to 20 μM inhibits MT1-MMP gelatinolytic and caseinolytic activity, blocks MT1-MMPactivation of pro-MMP-2, and decreases invasiveness of HT-1080 fibrosarcoma cells [1]. Most of the MICs of CMT-3 against filamentous fungi are found to be between 0.25 and 8 μg/mL, and the inhibition of viability of these fungi by incyclinide is routinely higher than 90% [2].
In vivo Probably by reducing the number of osteoclasts at the compression side, Incyclinide suppresses tooth movement in the rat. Reduced MMP activity by incyclinide might also directly inhibit degradation of the organic bone matrix. This might be due to the induction of apoptosis in activated osteoclasts or reduced osteoclast migration [3].
Synonyms COL-3, CMT-3
Molecular Weight 371.34
Formula C19H17NO7
CAS No. 15866-90-7

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 95 mg/mL (255.83 mM)

TargetMolReferences and Literature

1. Lee HM, et al. CMT-3, a non-antimicrobial tetracycline (TC), inhibits MT1-MMPactivity: relevance to cancer. Curr Med Chem. 2001 Feb;8(3):257-60. 2. Liu Y, A chemically modified tetracycline (CMT-3) is a new antifungal agent. Antimicrob Agents Chemother. 2002 May;46(5):1447-54. 3. Bildt MM, et al. CMT-3 inhibits orthodontic tooth displacement in the rat. Arch Oral Biol. 2007 Jun;52(6):571-8.

Related compound libraries

This product is contained In the following compound libraries:
Anti-Cancer Drug Library Anti-Cancer Clinical Compound Library Anti-Cancer Active Compound Library Protease Inhibitor Library Clinical Compound Library Drug Repurposing Compound Library Inhibitor Library Bioactive Compounds Library Max Anti-Fibrosis Compound Library Bioactive Compound Library

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Keywords

Incyclinide 15866-90-7 Proteases/Proteasome MMP CMT3 COL 3 Matrix metalloproteinases inhibit Inhibitor COL3 CMT 3 COL-3 CMT-3 inhibitor

 

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