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Homobutein

Catalog No. TN4220 CAS 34000-39-0

Synonyms: 3-O-Methylbutein, 2',4,4'-Trihydroxy-3-methoxychalcone

Homobutein (3-O-Methylbutein) is a dual inhibitor of HDACs and NF-κB with IC50s of 190 and 38 μM. Homobutein is an iron chelator with anticancer, anti-inflammatory, antiparasite, and antioxidation activities.

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Homobutein, CAS 34000-39-0

Pack Size	Availability	Price/USD
1 mg	In stock	$ 195.00
2 mg	In stock	$ 293.00
5 mg	In stock	$ 447.00
10 mg	In stock	$ 659.00
25 mg	In stock	$ 987.00
50 mg	In stock	$ 1,380.00

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Purity: 99.50%

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Description	Homobutein (3-O-Methylbutein) is a dual inhibitor of HDACs and NF-κB with IC50s of 190 and 38 μM. Homobutein is an iron chelator with anticancer, anti-inflammatory, antiparasite, and antioxidation activities.
In vitro	Homobutein (1 μg/mL) inhibits the growth of Toxoplasma gondii by 19.48%[1] with IC50s of 15.0 and 16.1 µM for W2 and D6 strains of P. falciparum[2]. Homobutein (20 - 40 μM) inhibits the viability and TNFα-induced NF-κB activity of K562 cells[4].
Source	Natural Products > Asteraceae > Dahlia

Synonyms	3-O-Methylbutein, 2',4,4'-Trihydroxy-3-methoxychalcone
Molecular Weight	286.28
Formula	C16H14O5
CAS No.	34000-39-0

Storage

store at low temperature

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Adeyemi OS, et al. In Vitro Screening to Identify Anti-Toxoplasma Compounds and In Silico Modeling for Bioactivities and Toxicity. Yale J Biol Med. 2019 Sep 20;92(3):369-383. 2. Yenesew A, et al. Anti-plasmodial flavonoids from the stem bark of Erythrina abyssinica. Phytochemistry. 2004 Nov;65(22):3029-32. 3. Serobatse K, et al. Antioxidant and antimalarial properties of butein and homobutein based on their ability to chelate iron (II and III) cations: a DFT study in vacuo and in solution. European Food Research and Technology, 2016, 242(1): 71-90. 4. Orlikova B, et al. Natural chalcones as dual inhibitors of HDACs and NF-κB. Oncol Rep. 2012 Sep;28(3):797-805.

Related compound libraries

This product is contained In the following compound libraries：

Immunology/Inflammation Compound Library RO5 Drug-like Natural Product Library Natural Product Library for HTS

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Keywords

Homobutein 34000-39-0 Chromatin/Epigenetic DNA Damage/DNA Repair Immunology/Inflammation Microbiology/Virology NF-Κb oxidation-reduction Parasite HDAC Immunology/Inflammation related Antioxidant NF-κB 3-O-Methylbutein 2',4,4'-Trihydroxy-3-methoxychalcone inhibitor inhibit

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