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Gypenoside XLVI

Catalog No. T2S1593 CAS 94705-70-1

Gypenoside XLVI shows strong cytotoxic activity against A549 cells, with the IC50 values of 52.63±8.31 ug/ml.

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Gypenoside XLVI, CAS 94705-70-1

Pack Size	Availability	Price/USD
1 mg	In stock	$ 74.00
5 mg	In stock	$ 173.00
10 mg	In stock	$ 257.00
25 mg	In stock	$ 432.00
50 mg	In stock	$ 638.00
1 mL * 10 mM (in DMSO)	In stock	$ 270.00

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Purity: 98.59%

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Description	Gypenoside XLVI shows strong cytotoxic activity against A549 cells, with the IC50 values of 52.63±8.31 ug/ml.
In vitro	Gynostemma pentaphyllum (Thunb.) Makino is one of the well-known traditional Chinese herbal medicines, which has been demonstrated to be effective against chronic diseases, such as lung cancer. In the present study, seven dammarane-type compounds were isolated from the raw, heat processed and alkaline hydrolyzed G. Pentaphyllum and compared for their cytotoxic activities against non-small cell lung carcinoma A549 cells using MTT cytotoxicity assay. METHODS AND RESULTS: By means of chemical and spectroscopic methods, their structures were established as gypenoside LVI, Gypenoside XLVI, gypenoside L, gypenoside LI, damulin A, damulin B and 20S-dammar-24-en-2α, 3β, 12β, 20-tetrol. Gypenoside LVI, Gypenoside XLVI, gypenoside L, gypenoside LI, damulin A, damulin B and 20S-dammar-24-en-2α,3β,12β,20-tetrol all showed strong cytotoxic activity against A549 cells, with the IC50 values of 105.89±2.48, 52.63±8.31, 34.94±4.23, 50.96±9.55, 26.98±0.51, 4.56±0.58, 12.54±0.53 μg/ml respectively, whereas the IC50 value of 20S-Rg3 (positive control) was 55.36±3.20 μg/ml. Comparing their structures with cytotoxic activity, these compounds might possess some kind of structure-activity relationship. CONCLUSIONS: Based on the structure and cytotoxic activity relationships of these seven constituents, the OH group in C-2, the double bond in C20(21) and C20(22) positions, the connected sugar number and the configuration in C-20 were important for cytotoxic activity against A549 cells.
Source	Natural Products > Araliaceae > Panax

Molecular Weight	963.15
Formula	C48H82O19
CAS No.	94705-70-1

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 25 mg/mL (25.96 mM)

References and Literature

1. Cytotoxic activity of gypenosides and gynogenin from Gynostemma pentaphyllum against A549 cells. Faseb J., 2014, 28(1).

Related compound libraries

This product is contained In the following compound libraries：

Miao medicine Compound Library Anti-Cancer Active Compound Library Anti-Cancer Compound Library Anti-Lung Cancer Compound Library Terpene Natural Product Library Bioactive Compound Library NO PAINS Compound Library Natural Product Library for HTS Bioactive Compounds Library Max Selected Plant-Sourced Compound Library

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Gypenoside XLVI 94705-70-1 Others inhibit Inhibitor inhibitor

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