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Glycolic acid

Catalog No. T5985 CAS 79-14-1

Glycolic acid is an inhibitor of tyrosinase, suppressing melanin formation,and used in skincare products

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Glycolic acid, CAS 79-14-1

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500 mg	In stock	$ 41.00
1 g	In stock	$ 48.00
1 mL * 10 mM (in DMSO)	In stock	$ 45.00

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Purity: 98%

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Description	Glycolic acid is an inhibitor of tyrosinase, suppressing melanin formation,and used in skincare products
In vivo	Glycolic acid(GA) reduced the production of UVB-induced nuclear factor kappa B (NF-κB)-dependent inflammatory mediators [interleukin (IL)-1β, IL-6, IL-8, cyclooxygenase (COX)-2, tumor necrosis factor-α, and monocyte chemoattractant protein (MCP-1)] at both mRNA and protein levels. GA inhibited the UVB-induced promoter activity of NF-κB in HaCaT cells. GA attenuated the elevation of senescence associated with β-galactosidase activity but did not affect the wound migration ability. The topical application of GA inhibited the genes expression of IL-1β, IL-6, IL-8, COX-2, and MCP-1 in UVB-exposed mouse skin. The mice to UVB irradiation after GA was topically applied for 9 consecutive days and reported that 1-1.5% of GA exerted anti-inflammatory effects on mouse skin[1]
Animal Research	The effects of different concentrations of Glycolic acid(GA) on the inflammatory response of human keratinocytes HaCaT cells and C57BL/6J mice dorsal skin.?After GA was topically applied, HaCaT and mice skin were exposed to UVB irradiation[1].

Molecular Weight	76.05
Formula	C2H4O3
CAS No.	79-14-1

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 100 mg/mL (1314.92 mM)

References and Literature

1. Tang S C , Liao P Y , Hung S J , et al. Topical application of glycolic acid suppresses the UVB induced IL-6, IL-8, MCP-1 and COX-2 inflammation by modulating NF-κB signaling pathway in keratinocytes and mice skin[J]. Journal of Dermatological Science, 2017:S092318111630915X.

Related compound libraries

This product is contained In the following compound libraries：

Drug Repurposing Compound Library Microbial Natural Product Library Tobacco Monomer Library Inhibitor Library Selected Plant-Sourced Compound Library Natural Product Library Clinical Compound Library Approved Drug Library Chinese Pharmacopoeia Natural Product Library Anti-Inflammatory Traditional Chinese Medicine Compound Library

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Keywords

Glycolic acid 79-14-1 Metabolism Proteases/Proteasome Endogenous Metabolite Tyrosinase Inhibitor inhibit inhibitor

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