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Gliquidone

Catalog No. T0371 CAS 33342-05-1

Synonyms: AR-DF 26, Glurenorm

Gliquidone (AR-DF 26) is a potent, second-generation sulfonylurea with antihyperglycemic activity. Like other second-generation compounds, gliquidone exerts greater binding affinity to SUR1 and increased potency compared to first-generation compounds. In addition, this agent exerts peroxisome proliferator-activated receptor (PPAR) gamma agonistic activity.

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Gliquidone, CAS 33342-05-1

Pack Size	Availability	Price/USD
50 mg	In stock	$ 47.00
100 mg	In stock	$ 57.00
200 mg	In stock	$ 83.00
500 mg	In stock	$ 138.00
1 mL * 10 mM (in DMSO)	In stock	$ 48.00

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Purity: 100%

Purity: 99.93%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Gliquidone (AR-DF 26) is a potent, second-generation sulfonylurea with antihyperglycemic activity. Like other second-generation compounds, gliquidone exerts greater binding affinity to SUR1 and increased potency compared to first-generation compounds. In addition, this agent exerts peroxisome proliferator-activated receptor (PPAR) gamma agonistic activity.
Targets&IC50	K+ channel:27.2 nM
In vitro	Intraventricular administration of 0.06–16 μg Gliquidone to each mouse counteracts the antinociceptive effects of tramadol, morphine, and methadone. A dose of 6 μg Gliquidone intraventricularly administered to each mouse inhibits the antinociceptive responses induced by subcutaneous injections of 0.125 mg/kg clonidine and 0.30 mg/kg chlorthalidone; however, a 3 μg dose is ineffective. In male Swiss albino mice, intraventricular injections of 0.1–1.0 μg Gliquidone dose-dependently suppress the antinociceptive effects of amitriptyline and chlorphenamine. In diabetic rats, a 10 mg/kg dose of Gliquidone significantly reduces blood pressure, diminishes non-enzymatic glycation, lowers total protein levels in the lens, and notably increases glutathione levels in the lens.

Synonyms	AR-DF 26, Glurenorm
Molecular Weight	527.63
Formula	C27H33N3O6S
CAS No.	33342-05-1

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 97 mg/mL (183.8 mM)

Ethanol: 6 mg/mL (11.37 mM)

References and Literature

1. Angel I, et al. Fundam Clin Pharmacol, 1991, 5(2), 107-115. 2. Galeotti N, et al. Neuropharmacology, 2001, 40(1), 75-84. 3. Ocana M, et al. Br J Pharmacol, 1995, 114(6), 1296-1302. 4. Galeotti N, et al. Br J Pharmacol, 1999, 126(5), 1214-1220. 5. Yarat A, et al. Free Radic Biol Med, 2001, 31(9), 1038-1042. 6. Capoci I R G, Faria D R, Sakita K M, et al. Repurposing approach identifies new treatment options for invasive fungal disease[J]. Bioorganic chemistry. 2019 Mar;84:87-97.

Citations

1. Capoci I R G, Faria D R, Sakita K M, et al. Repurposing approach identifies new treatment options for invasive fungal disease. Bioorganic Chemistry. 2019 Mar;84:87-97

Related compound libraries

This product is contained In the following compound libraries：

Drug Repurposing Compound Library Anti-Cancer Approved Drug Library Anti-Cancer Drug Library Anti-Metabolism Disease Compound Library Potassium Channel Blocker Library Bioactive Compounds Library Max Human Metabolite Library Approved Drug Library FDA-Approved & Pharmacopeia Drug Library Anti-COVID-19 Compound Library

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Gliquidone 33342-05-1 Membrane transporter/Ion channel Potassium Channel AR-DF 26 Inhibitor inhibit Glurenorm inhibitor

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