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Giredestrant tartrate

Catalog No. T11236 CAS 2407529-33-1

Synonyms: Estrogen receptor antagonist 1

Giredestrant tartrate (Estrogen receptor antagonist 1) is a novel, orally active, selective and effective non-steroidal estrogen receptor antagonist. Giredestrant tartrate strongly binds to ER, resulting in the failure of ER to activate the transcription of targeted genes and promoting the degradation of ER protein. Giredestrant tartrate can be used to treat tumor diseases.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

Giredestrant tartrate Chemical Structure

Giredestrant tartrate, CAS 2407529-33-1

Pack Size	Availability	Price/USD
1 mg	In stock	$ 195.00
5 mg	In stock	$ 447.00
10 mg	In stock	$ 659.00
25 mg	In stock	$ 987.00
50 mg	In stock	$ 1,380.00
100 mg	In stock	$ 1,890.00
500 mg	In stock	$ 3,790.00

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Purity: 98.01%

ee: 96.71%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Giredestrant tartrate (Estrogen receptor antagonist 1) is a novel, orally active, selective and effective non-steroidal estrogen receptor antagonist. Giredestrant tartrate strongly binds to ER, resulting in the failure of ER to activate the transcription of targeted genes and promoting the degradation of ER protein. Giredestrant tartrate can be used to treat tumor diseases.
In vitro	Estrogen receptor antagonist 1 shows weak metabolism dependent inhibition of CYP2C9.Estrogen receptor antagonist 1 directly inhibits CYP3A4 with IC50 values of 6.5 µM (midazolam 1'-hydroxylation) and 26 µM (testosterone 6β-hydroxylation); IC50 for CYP2B6 and CYP2C8 inhibition were 13 µM and 21 µM, respectively.

Synonyms	Estrogen receptor antagonist 1
Molecular Weight	672.64
Formula	C31H37F5N4O7
CAS No.	2407529-33-1

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 55 mg/mL (81.77 mM)

References and Literature

1. Liang J, Zbieg JR, Blake RA, et al. GDC-9545 (Giredestrant): A Potent and Orally Bioavailable Selective Estrogen Receptor Antagonist and Degrader with an Exceptional Preclinical Profile for ER+ Breast Cancer. J Med Chem. 2021;64(16):11841-11856.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Drug Library Drug Repurposing Compound Library Anti-Cancer Active Compound Library Anti-Cancer Clinical Compound Library Nuclear Receptor Compound Library Bioactive Compounds Library Max Bioactive Compound Library Anti-Cancer Compound Library Clinical Compound Library

Related Products

Related compounds with same targets

Camizestrant TFA Quinestrol Chrysin ARV-471 WAY-200070 Ethynyl estradiol G-1 Giredestrant

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Keywords

Giredestrant tartrate 2407529-33-1 Endocrinology/Hormones Others Estrogen Receptor/ERR Giredestrant Tartrate Estrogen receptor antagonist 1 inhibitor inhibit

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