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Gefarnate

Catalog No. T7099 CAS 51-77-4

Gefarnate is a synthetic compound used for the treatment of gastric ulcers,and also used in the treatment of dry eye syndrome.

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Gefarnate, CAS 51-77-4

Pack Size	Availability	Price/USD
25 mg	In stock	$ 30.00
50 mg	In stock	$ 40.00
100 mg	In stock	$ 64.00
200 mg	In stock	$ 93.00
1 mL * 10 mM (in DMSO)	In stock	$ 44.00

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Purity: 97.10%

Biological Description

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Storage & Solubility Information

Description	Gefarnate is a synthetic compound used for the treatment of gastric ulcers,and also used in the treatment of dry eye syndrome.
In vivo	Gefarnate stimulated mucin-like glycoprotein secretion in conjunctival tissue in a dose-dependent manner. In the rabbit dry-eye model, application of gefarnate ointment to the eyes resulted in a dose-dependent decrease in rose bengal permeability in the cornea, with the effect being significant at concentrations of ≥0.3%. In the cat dry-eye model, application of gefarnate ointment resulted in a significant decrease in the corneal fluorescein staining score[1].
Animal Research	Conjunctival tissue isolated from rabbits was treated with gefarnate. Mucin-like glycoprotein was detected in the culture supernatant by an enzyme-linked lectin assay. Gefarnate ointment was topically applied to eyes once daily for 7 days in the rabbit dry-eye model, in which the lacrimal glands, Harderian gland, and nictitating membrane were removed, or for 4 weeks in the cat dry-eye model, in which the lacrimal gland and nictitating membrane were removed. Corneal epithelial damage was evaluated by measurement of corneal permeability by rose bengal in the rabbit model or by fluorescein staining in the cat model[1].

Molecular Weight	400.64
Formula	C27H44O2
CAS No.	51-77-4

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 100 mg/mL (249.60 mM)

References and Literature

1. Dota A , Takaoka-Shichijo Y , Nakamura M . Gefarnate stimulates mucin-like glycoprotein secretion in conjunctival tissue and ameliorates corneal epithelial damage in animal dry-eye models[J]. Clinical ophthalmology (Auckland, N.Z.), 2013, 7(default):211-217. 2. Ohta Y , Kobayashi T , Imai Y , et al. Effect of Gefarnate on Acute Gastric Mucosal Lesion Progression in Rats Treated with Compound 48/80, a Mast Cell Degranulator, in Comparison with That of Teprenone[J]. Biological & Pharmaceutical Bulletin, 2005, 28(8):1424-1430. 3. Du Y Q , Su T , Hao J Y , et al. Gastro-protecting effect of gefarnate on chronic erosive gastritis with dyspeptic symptoms[J]. Chinese Medical Journal, 2012, 125.

Related compound libraries

This product is contained In the following compound libraries：

Drug Repurposing Compound Library Bioactive Compounds Library Max Human Metabolite Library Bioactive Compound Library Clinical Compound Library FDA-Approved & Pharmacopeia Drug Library Approved Drug Library ReFRAME Related Library NO PAINS Compound Library

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Keywords

Gefarnate 51-77-4 Others Inhibitor inhibit inhibitor

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