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Gacyclidine

Catalog No. T27397 CAS 68134-81-6

Synonyms: GK 11, OTO311, OTO-311, OTO 311, GK-11

Gacyclidine (OTO311) is a small molecule N-methyl-D-aspartate (NMDA) receptor antagonist. Local injection of Gacyclidine in the cochlea inhibits salicylate-induced tinnitus and can be used to treat brain injury, spinal cord injury and tinnitus.

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Gacyclidine, CAS 68134-81-6

Pack Size	Availability	Price/USD
1 mg	In stock	$ 85.00
5 mg	In stock	$ 210.00
10 mg	In stock	$ 310.00
25 mg	In stock	$ 586.00
50 mg	In stock	$ 780.00
100 mg	In stock	$ 1,090.00
500 mg	In stock	$ 2,180.00

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Purity: 100%

ee: 97.76%

Purity: 99.35%

ee: 98.42%

Biological Description

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Description	Gacyclidine (OTO311) is a small molecule N-methyl-D-aspartate (NMDA) receptor antagonist. Local injection of Gacyclidine in the cochlea inhibits salicylate-induced tinnitus and can be used to treat brain injury, spinal cord injury and tinnitus.
In vitro	In primary cortical cultures, gacyclidine and its enantiomers, at 0.1 to 5.0 μM, prevent glutamate-induced neuronal death.[1]
In vivo	In rats, the in vivo neurotoxicity of gacyclidine is far lower than that of MK-801. No necrotic neurons were detected in animals sacrificed at 18 or 96 h after treatment with gacyclidine (1, 5, 10, or 20 mg/kg i.v.). At the highest (20 mg/kg) but not the lower doses (1-100 mg/kg) electron microscopy revealed the presence of few cytoplasmic or intramitochondrial vacuoles. Moreover, in rats, gacyclidine exerts a dose- and time-dependent neuroprotection in three models of spinal cord lesions. Beneficial effects of gacyclidine include reduction of lesion size and improvement of functional parameters after injury. In traumatic brain injury models, gacyclidine improves behavioral parameters and neuronal survival. Optimal protection is obtained when gacyclidine is administered at 0 to 30 min after injury.[1]

Synonyms	GK 11, OTO311, OTO-311, OTO 311, GK-11
Molecular Weight	263.44
Formula	C16H25NS
CAS No.	68134-81-6

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 2.63 mg/mL (10 mM), Sonication is recommended.

References and Literature

1. Hirbec H, et al. Gacyclidine: a new neuroprotective agent acting at the N-methyl-D-aspartate receptor. CNS Drug Rev. 2001 Summer;7(2):172-98. 2. Hoizey G, et al. Modified gas chromatographic-mass spectrometric assay for the determination of gacyclidine enantiomers in human plasma. J Chromatogr B Biomed Sci Appl. 1999 Aug 20;731(2):317-22. 3. Chenoweth JA, et al. Altered mental status and end organ damage associated with the use of gacyclidine: a case series. J Med Toxicol. 2015 Mar;11(1):115-20. 4. Lallement G, et al. Review of the value of gacyclidine (GK-11) as adjuvant medication to conventional treatments of organophosphate poisoning: primate experiments mimicking various scenarios of military or terrorist attack by soman. Neurotoxicology. 1999 Aug;20(4):675-84.

Related compound libraries

This product is contained In the following compound libraries：

Drug Repurposing Compound Library Anti-Neurodegenerative Disease Compound Library Bioactive Compound Library Bioactive Compounds Library Max

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Keywords

Gacyclidine 68134-81-6 Neuroscience NMDAR GK 11 OTO311 OTO-311 OTO 311 GK11 GK-11 inhibitor inhibit

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