Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Fuzapladib (IS-741) (IS-741) is a phospholipase A2 inhibitor that can inhibits the expression of Mac-1, a cell adhesion molecule. Fuzapladib blocks activation of adhesion molecules (integrin) expressed on the inflammatory cell surface to prevent inflammatory cells from adhering to vascular endothelial cells and infiltrating tissue and to control exacerbation of pancreatitis.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 98.00 | |
5 mg | In stock | $ 247.00 | |
10 mg | In stock | $ 372.00 | |
25 mg | In stock | $ 788.00 | |
50 mg | In stock | $ 1,230.00 | |
100 mg | In stock | $ 1,990.00 | |
500 mg | In stock | $ 3,920.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 355.00 |
Description | Fuzapladib (IS-741) (IS-741) is a phospholipase A2 inhibitor that can inhibits the expression of Mac-1, a cell adhesion molecule. Fuzapladib blocks activation of adhesion molecules (integrin) expressed on the inflammatory cell surface to prevent inflammatory cells from adhering to vascular endothelial cells and infiltrating tissue and to control exacerbation of pancreatitis. |
In vitro | Treatment with Fuzapladib(IS-741) 1μM for 3 h significantly inhibited the adhesion of HL-60 cells to HUVEC stimulated by lipopolysaccharide [1]. |
In vivo | Oral administration of Fuzapladib(IS-741) 50mg/kg significantly decreased the activity of myeloperoxidase (MPO) and the level of IL-8 in the ileum of rats for 7 consecutive days, and reduced the infiltration of inflammatory lesion multinucleate cells and Mac-1 positive cells, and effectively alleviated the ileitis induced by tritrobenzosulfonate (TNBS)[2]. |
Synonyms | IS-741 |
Molecular Weight | 379.4 |
Formula | C15H20F3N3O3S |
CAS No. | 141283-87-6 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 3.79 mg/mL (10 mM)
You can also refer to dose conversion for different animals. More
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Fuzapladib 141283-87-6 Metabolism Phospholipase IS 741 IS741 IS-741 inhibitor inhibit