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Giripladib

Catalog No. T31929 CAS 865200-20-0

Synonyms: PLA 695, PLA-695, PLA695

Giripladib (PLA695)(PLX-695) is a cPLA2-specific inhibitor that inhibits the radiation-induced increase of phosphorylated ERK and phosphorylated Akt in endothelial cells.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

Giripladib, CAS 865200-20-0

Pack Size	Availability	Price/USD
1 mg	In stock	$ 195.00
5 mg	In stock	$ 448.00
10 mg	In stock	$ 658.00
25 mg	In stock	$ 987.00
50 mg	In stock	$ 1,380.00
100 mg	In stock	$ 1,890.00
1 mL * 10 mM (in DMSO)	In stock	$ 656.00

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Purity: 99.68%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

Giripladib (PLA695)(PLX-695) is a cPLA2-specific inhibitor that inhibits the radiation-induced increase of phosphorylated ERK and phosphorylated Akt in endothelial cells.

Synonyms	PLA 695, PLA-695, PLA695
Molecular Weight	745.25
Formula	C41H36ClF3N2O4S
CAS No.	865200-20-0

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 7.45 mg/mL (10 mM)

References and Literature

1. Duvernay MT, et al. Platelet Lipidomic Profiling: Novel Insight into Cytosolic Phospholipase A2α Activity and Its Role in Human Platelet Activation. Biochemistry. 2015 Sep 15;54(36):5578-88. 2. Thotala D, et al. Cytosolic phospholipaseA2 inhibition with PLA-695 radiosensitizes tumors in lung cancer animal models. PLoS One. 2013 Jul 19;8(7):e69688.

Related compound libraries

This product is contained In the following compound libraries：

Drug Repurposing Compound Library Inhibitor Library Immunology/Inflammation Compound Library Bioactive Compounds Library Max Clinical Compound Library Bioactive Compound Library

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

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What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?
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What volume of a given 10 mM stock solution is required to make 20ml of a 50 μM solution?
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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Giripladib 865200-20-0 Metabolism Phospholipase PLA 695 PLA-695 PLA695 inhibitor inhibit

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.