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Fusidic acid sodium salt

Catalog No. T1289 CAS 751-94-0

Synonyms: Sodium fusidate, Fusidate Sodium, SQ-16360, Fucidin, 夫西地酸钠

Fusidate Sodium is a sodium salt form of fusidic acid, a bacteriostatic antibiotic derived from the fungus Fusidium coccineum and used as a topical medication to treat skin infections.

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Fusidic acid sodium salt, CAS 751-94-0

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Fusidate Sodium is a sodium salt form of fusidic acid, a bacteriostatic antibiotic derived from the fungus Fusidium coccineum and used as a topical medication to treat skin infections.
In vivo	Fusidin(Fusidate Sodium) ameliorates EAM, at least partly, through an inhibitory action on the secretion of TNF-a[1]. It markedly attenuates clinical and histological signs of immunoinflammatory diabetes mellitus in mice given streptozotocin(SZ). The effect is dose-dependent, observed in three different strains of mice. Thus, fusidin might have an antidiabetogenic effect[2].
Kinase Assay	Binding assays: Binding assays are performed as previously described (Allenby et al., 1993, 1994). Briefly, labeled and unlabeled retinoids are added to nucleosol or cytosolic fractions in ethanol so that the total amount of ethanol added is constant in all tubes and did not exceed 2% of the incubation volume. The receptor preparations are incubated with retinoids at 4°C for 4–6 hr. Sephadex PD-10 desalting columns are used to separate bound radioligand from free radioligand after equilib- rium is achieved. For competitive binding assays, varying concentrations of unlabeled competing ligand are incubated with the appropriate nucleosol or cytosol in the presence of a fixed concentration of [3H]tRA (sp. act. 49.3 Ci/mmol) or [3H]9-cis RA (sp. act. 24.0 Ci/mmol). Final concentrations of [3H] tRA and [3H]9-cis RA for nuclear receptor binding assays are 5 nM. Final concentrations of [3H] tRA for CRABP binding assays is 30 nM. The IC50s are calculated as described above (DeLean et al., 1978). For saturation kinetics, increasing concentrations of radiolabeled ligand ([3H]tRA sp. act. 49.3 Ci/mmol, [3H]TTNPB sp. act. 5.5 Ci/ mmol) are added to the nucleosol of the appropriate receptor subtype in the presence (nonspecific binding) or absence (total binding) of a 100-fold molar excess of the corresponding unlabeled retinoid. Specific binding is defined as the total binding minus nonspecific binding. Saturation kinetics are calculated as previously described (Scatchard, 1949; Grippo and Gudas, 1987; Levin et al., 1992).

Synonyms	Sodium fusidate, Fusidate Sodium, SQ-16360, Fucidin, 夫西地酸钠
Molecular Weight	538.701
Formula	C31H47NaO6
CAS No.	751-94-0

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

Ethanol: 93 mg/mL (172.6 mM)

H2O: 92 mg/mL (170.8 mM)

DMSO: 93 mg/mL (172.6 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Milenkovć M, et al. Pharmazie. 2007, 62(6):445-8. 2. Nicoletti F, et al. J Autoimmun. 2000, 15(4):395-405. 3. Li J, Liu X, Tan L, et al. Zinc-doped Prussian blue enhances photothermal clearance of Staphylococcus aureus and promotes tissue repair in infected wounds[J]. Nature communications. 2019, 10(1): 1-15.

Citations

1. Li J, Liu X, Tan L, et al. Zinc-doped Prussian blue enhances photothermal clearance of Staphylococcus aureus and promotes tissue repair in infected wounds. Nature communications. 2019 Oct 3;10(1):4490. doi: 10.1038

Related compound libraries

This product is contained In the following compound libraries：

Antibiotics Library Oxidation-Reduction Compound Library Immunology/Inflammation Compound Library Drug Repurposing Compound Library Approved Drug Library FDA-Approved & Pharmacopeia Drug Library Anti-Bacterial Compound Library Anti-Aging Compound Library NMPA-Approved Drug Library Anti-Infection Compound Library

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Keywords

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