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Fulacimstat

Catalog No. TQ0035 CAS 1488354-15-9

Synonyms: BAY1142524

Fulacimstat (BAY1142524) (BAY1142524) is a chymase inhibitor, with IC50s of 3, 4 nM for hamster and human chymase enzyme, respectively.

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Fulacimstat, CAS 1488354-15-9

Pack Size	Availability	Price/USD
1 mg	In stock	$ 135.00
5 mg	In stock	$ 289.00
10 mg	In stock	$ 413.00
25 mg	In stock	$ 692.00
50 mg	In stock	$ 985.00
100 mg	In stock	$ 1,330.00
1 mL * 10 mM (in DMSO)	In stock	$ 297.00

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Purity: 99.77%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Fulacimstat (BAY1142524) (BAY1142524) is a chymase inhibitor, with IC50s of 3, 4 nM for hamster and human chymase enzyme, respectively.
Targets&IC50	Hamster chymase enzyme:3 nM, Chymase:4 nM
In vivo	Isoprenaline induces cardiac fibrosis (24.4%) in hamsters, which is reduced dose-dependently by Fulacimstat (16.4%, 12.4%, 10.9% at 1, 3 and 10 mg/kg respectively). Four weeks after MI, hamster hearts show increased end-diastolic pressure and reduce contractility and relaxation. Compared to placebo (19.3±2 mmHg), Fulacimstat at 10 mg/kg reduces significantly the end-diastolic pressure (13.2±1.4 mmHg) without any effects on blood pressure or heart rate. Moreover, treatment with Fulacimstat reduces the fibrotic area and improves the cardiac response to adrenergic stimulation [1].

Synonyms	BAY1142524
Molecular Weight	487.38
Formula	C23H16F3N3O6
CAS No.	1488354-15-9

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 5 mg/mL (10.26 mM), Sonication is recommended.

References and Literature

1. Hanna Tinel, et al. Abstract 13624: A Novel Chymase Inhibitor BAY 1142524 Reduces Fibrosis and Improves Cardiac Function After Myocardial Infarction in Hamster. Circulation. 2018;136:A13624.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Drug Repurposing Compound Library Anti-Diabetic Compound Library ReFRAME Related Library NO PAINS Compound Library Clinical Compound Library Bioactive Compound Library Anti-Cardiovascular Disease Compound Library Anti-Metabolism Disease Compound Library Orally Active Compound Library

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

Note:

Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Fulacimstat 1488354-15-9 Others inhibit BAY1142524 Inhibitor BAY 1142524 BAY-1142524 inhibitor

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