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Fadrozole

Name: Fadrozole
Brand: TargetMol
SKU: T7197
Price: 42 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T7197Cas No. 102676-47-1

Fadrozole is a nonsteroidal aromatase inhibitor with potential antineoplastic activity(IC50 : 6.4 nM)

Fadrozole

🥰Excellent

Purity: 99.47%

Catalog No. T7197Cas No. 102676-47-1

Fadrozole is a nonsteroidal aromatase inhibitor with potential antineoplastic activity(IC50 : 6.4 nM)

Pack Size	Price	Availability
5 mg	$42	In Stock
10 mg	$68	In Stock
25 mg	$130	In Stock
50 mg	$225	In Stock
100 mg	$389	In Stock
200 mg	$573	In Stock
1 mL x 10 mM (in DMSO)	$46	In Stock

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Batch Information

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Purity:99.47%

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	Fadrozole is a nonsteroidal aromatase inhibitor with potential antineoplastic activity(IC50 : 6.4 nM)
Targets&IC50	Aromatase:6.4 nM
In vivo	Fadrozole is a model aromatase inhibitor that shown to suppress estrogen production in the ovaries of fish.
Animal Research	Adult female fathead minnows (Pimephales promelas) were exposed via water to 0, 5, or 50μg fadrozole/L for a time-course of 0.5, 1, 2, 4, and 6h, or 0 or 50μg fadrozole/L for a time-course of 6, 12, and 24h. Examined ex vivo ovarian 17β-estradiol (E2) and testosterone (T) production, and plasma E2 concentrations from each study.

Chemical Properties

Molecular Weight	223.27
Formula	C₁₄H₁₃N₃
Cas No.	102676-47-1
Smiles	N#Cc1ccc(cc1)C1CCCc2cncn12
Relative Density.	1.2g/cm3
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 100 mg/mL (447.89 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.4789 mL	22.3944 mL	44.7888 mL	223.9441 mL
5 mM	0.8958 mL	4.4789 mL	8.9578 mL	44.7888 mL
10 mM	0.4479 mL	2.2394 mL	4.4789 mL	22.3944 mL
20 mM	0.2239 mL	1.1197 mL	2.2394 mL	11.1972 mL
50 mM	0.0896 mL	0.4479 mL	0.8958 mL	4.4789 mL
100 mM	0.0448 mL	0.2239 mL	0.4479 mL	2.2394 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc