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Fadrozole

Catalog No. T7197 CAS 102676-47-1

Fadrozole is a nonsteroidal aromatase inhibitor with potential antineoplastic activity(IC50 : 6.4 nM)

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Fadrozole, CAS 102676-47-1

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Purity: 98%

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Description	Fadrozole is a nonsteroidal aromatase inhibitor with potential antineoplastic activity(IC50 : 6.4 nM)
Targets&IC50	Aromatase:6.4 nM
In vivo	Fadrozole is a model aromatase inhibitor that shown to suppress estrogen production in the ovaries of fish.
Animal Research	Adult female fathead minnows (Pimephales promelas) were exposed via water to 0, 5, or 50μg fadrozole/L for a time-course of 0.5, 1, 2, 4, and 6h, or 0 or 50μg fadrozole/L for a time-course of 6, 12, and 24h. Examined ex vivo ovarian 17β-estradiol (E2) and testosterone (T) production, and plasma E2 concentrations from each study.

Molecular Weight	223.279
Formula	C14H13N3
CAS No.	102676-47-1

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 100 mg/mL (447.89 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Schroeder A L , Ankley G T , Habib T , et al. Rapid Effects of the Aromatase Inhibitor Fadrozole on Steroid Production and Gene Expression in the Ovary of Female Fathead Minnows ( Pimephales promelas )[J]. General and Comparative Endocrinology, 2017:S0016648017301521.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Compound Library Endocrinology-Hormone Compound Library Inhibitor Library Drug-induced Liver Injury (DILI) Compound Library Drug Repurposing Compound Library Anti-Cancer Approved Drug Library Anti-Cancer Active Compound Library Anti-Breast Cancer Compound Library Approved Drug Library Anti-Cancer Drug Library

Related Products

Related compounds with same targets

Eriodictyol chalcone Fadrozole hydrochloride Fadrozole Oleuropein Endoxifen Calceolarioside B Obacunone alpha-Naphthoflavone

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Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Keywords

Fadrozole 102676-47-1 内分泌与激素 Aromatase (Rac)-FAD286 inhibit CGS 16949A Inhibitor inhibitor

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