Powder: -20°C for 3 years | In solvent: -80°C for 1 year
FPA-124, a cell-permeable copper complex and selective Akt inhibitor with an IC50 of 0.1 μM, engages the pleckstrin homology (PH) and kinase domains of Akt, inducing apoptosis.
Description | FPA-124, a cell-permeable copper complex and selective Akt inhibitor with an IC50 of 0.1 μM, engages the pleckstrin homology (PH) and kinase domains of Akt, inducing apoptosis. |
In vitro | FPA-124 exhibits dose-dependent growth inhibitory effects with IC50s of 7, 10, 34, and 55 μM in BT20, PC-3, COLO 357 and BxPC-3 cancer cell lines, respectively. |
In vivo | FPA-124 demonstrates inhibitory effects on PKB (Akt protein) and leads to the inactivation of NF-κB within a validated orthotopic pancreatic tumor model utilizing COLO 357 cells. |
Molecular Weight | 381.73 |
Formula | C11H9Cl2CuN3O2S |
CAS No. | 902779-59-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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FPA-124 902779-59-3 Others FPA124 FPA 124 inhibitor inhibit