Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Etoricoxib (MK-663) is a synthetic, nonsteroidal anti-inflammatory drug (NSAID) with antipyretic, analgesic, and potential antineoplastic properties. Etoricoxib specifically binds to and inhibits the enzyme cyclooxygenase-2 (COX-2), resulting in inhibition of the conversion of arachidonic acid into prostaglandins. Inhibition of COX-2 may induce apoptosis and inhibit tumor cell proliferation and angiogenesis.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
5 mg | In stock | $ 34.00 | |
10 mg | In stock | $ 50.00 | |
25 mg | In stock | $ 72.00 | |
50 mg | In stock | $ 102.00 | |
100 mg | In stock | $ 156.00 | |
200 mg | In stock | $ 261.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 50.00 |
Description | Etoricoxib (MK-663) is a synthetic, nonsteroidal anti-inflammatory drug (NSAID) with antipyretic, analgesic, and potential antineoplastic properties. Etoricoxib specifically binds to and inhibits the enzyme cyclooxygenase-2 (COX-2), resulting in inhibition of the conversion of arachidonic acid into prostaglandins. Inhibition of COX-2 may induce apoptosis and inhibit tumor cell proliferation and angiogenesis. |
Targets&IC50 | COX-2:1.1 μM COX-1 |
In vivo | The preferential cyclooxygenase-2 inhibitor etoricoxib significantly reduces the anticonvulsant action of phenytoin and significantly increases the beneficial action of diazepam against maximal electroshock and pentylenetetrazole-induced convulsions in a mouse model[1]. Etoricoxib has the potential to act as an anti-apoptotic and anti- proliferative agent in the colon[2]. |
Cell Research | Human colon carcinoma cell line HCT-116 are treated with various coxibs for 2 h. Subsequently, the cells are harvested and the sphingolipids isolated and determined by LC-MS/MS. (Only for Reference) |
Synonyms | Arcoxia, MK-663, Tauxib, L-791456, Nucoxia, Desvenlafaxine |
Molecular Weight | 358.84 |
Formula | C18H15ClN2O2S |
CAS No. | 202409-33-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Ethanol: 43 mg/mL (119.8 mM)
DMSO: 66 mg/mL (183.9 mM)
H2O: < 1 mg/mL (insoluble or slightly soluble)
You can also refer to dose conversion for different animals. More
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
Etoricoxib 202409-33-4 Immunology/Inflammation Neuroscience COX MK-0663 L 791456 MK 0663 Arcoxia Inhibitor MK663 MK-663 Tauxib L-791456 inhibit MK0663 MK 663 Nucoxia Cyclooxygenase L791456 Desvenlafaxine inhibitor