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Esculin

Name: Esculin
Brand: TargetMol
SKU: T2885
Price: 43 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T2885Cas No. 531-75-9

Alias Aesculin

Esculin (Aesculin) is a glucoside found in horse chestnuts.

Esculin

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Purity: 99.83%

Catalog No. T2885Alias AesculinCas No. 531-75-9

Esculin (Aesculin) is a glucoside found in horse chestnuts.

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
500 mg	$43	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$48	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.83%

Appearance:Solid

Color:White

Resource Download

COA HNMR HPLC

Product Introduction

Esculin AI Summary

Esculin exhibits a diverse spectrum of bioactivities. It has been tested for its inhibitory effects on Monoamine Oxidase (MAO), showing 9.0% inhibition on MAO-A and 7.0% on MAO-B at a concentration of 100 μM. Additionally, it inhibits purified recombinant integrase, with 40.8% and 29.6% inhibition in the 3''-processing method, and 67.7% and 34.2% in the strand transfer method, indicating potential integrase function inhibition. The compound shows modest activity against HIV1 reverse transcriptase (IC50 > 200.0 μg/mL) and less than 30.0% inhibition of COX2 at 100 μM. Esculin also targets several other enzymes and receptors. It inhibits Cast-iron among others, hydroxysteroid dehydrogenase 4, human Jumonji domain containing 2E, Caspase-1, Caspase-7, Cruzain, Aldehyde Dehydrogenase 1, IMPase, ROR gamma transcriptional activity, HPGD, glucocerebrosidase, 15-human lipoxygenase 2, and human alpha-Galactosidase. It acts as an alpha-amylase inhibitor (IC50 1670 μM), and exhibits slight inhibition on Saccharomyces cerevisiae alpha-glucosidase (1.8% at 200 μM). Additionally, it functions as a bitter taste receptor agonist targeting the TAS2R16 receptor with an activity level of 4.0 mM. This compound shows antiviral activity against SARS-CoV-2 with IC50 values greater than 20 μM against viral-induced cytotoxicity in VERO-6 cells, and demonstrates moderate inhibitory effects on human HDAC6, affecting enzymatic activity variably depending on the peptide substrate. Furthermore, it binds various DNA structures, such as telomeric IKF1 G4 quadruplex DNA and ILPR G4 quadruplex DNA, by influencing their melting temperatures. Lastly, Esculin inhibits Macrophage Migration Inhibitory Factor (MIF) tautomerase with an IC50 value of 160 μM and a Ki value of 143 μM, showing 15.0% inhibition of MIF-induced cell migration. Overall, Esculin exhibits a multifaceted bioactivity profile, indicating its potential for therapeutic applications across various biochemical pathways and disease targets..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Esculin (Aesculin) is a glucoside found in horse chestnuts.
Synonyms	Aesculin

Chemical Properties

Molecular Weight	340.28
Formula	C₁₅H₁₆O₉
Cas No.	531-75-9
Smiles	OCC1OC(Oc2cc3ccc(=O)oc3cc2O)C(O)C(O)C1O
Relative Density.	1.679 g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 40 mg/mL (117.55 mM), Sonication is recommended.

H2O: 2 mg/mL (5.88 mM), Sonication is recommended.

Ethanol: 11 mg/mL (32.33 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (5.88 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

H2O/Ethanol/DMSO

	1mg	5mg	10mg	50mg
1 mM	2.9388 mL	14.6938 mL	29.3876 mL	146.9378 mL
5 mM	0.5878 mL	2.9388 mL	5.8775 mL	29.3876 mL

Ethanol/DMSO

	1mg	5mg	10mg	50mg
10 mM	0.2939 mL	1.4694 mL	2.9388 mL	14.6938 mL
20 mM	0.1469 mL	0.7347 mL	1.4694 mL	7.3469 mL

DMSO

	1mg	5mg	10mg	50mg
50 mM	0.0588 mL	0.2939 mL	0.5878 mL	2.9388 mL
100 mM	0.0294 mL	0.1469 mL	0.2939 mL	1.4694 mL

Calculator

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc