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Oxidation-reduction Free radical scavengers Echinatin

Echinatin

Catalog No. T3926   CAS 34221-41-5
Synonyms: Retrochalcone

Echinatin disturb the mitochondrial energy transfer reactions and membrane permeability, at a low concentration cause deterioration of respiratory control and oxidative phosphorylation of isolated rat liver mitochondria, inhibits DNP-ATPase activity while stimulating range latent ATPase activity. Echinatin has significant antioxidant activities, it shows strong scavenging activity toward the ABTS + radical, it also dose-dependently inhibits LPS induced reactive oxygen species (ROS) production in RAW 264.7 cells and inhibits the production of nitric oxide (NO), interleukin-6 (IL-6) and prostaglandin E2 (PGE2) in LPS-induced macrophage cells.

Echinatin, CAS 34221-41-5
Pack Size Availability Price/USD Quantity
1 mg In stock 50.00
5 mg In stock 110.00
10 mg In stock 185.00
1 mL * 10 mM (in DMSO) In Stock 110.00
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Purity 98.38%
Purity 99.61%
Purity 98.49%
Purity 98.00%
Purity 97.42%
Biological Description
Chemical Properties
Storage & Solubility Information
Description Echinatin disturb the mitochondrial energy transfer reactions and membrane permeability, at a low concentration cause deterioration of respiratory control and oxidative phosphorylation of isolated rat liver mitochondria, inhibits DNP-ATPase activity while stimulating range latent ATPase activity. Echinatin has significant antioxidant activities, it shows strong scavenging activity toward the ABTS + radical, it also dose-dependently inhibits LPS induced reactive oxygen species (ROS) production in RAW 264.7 cells and inhibits the production of nitric oxide (NO), interleukin-6 (IL-6) and prostaglandin E2 (PGE2) in LPS-induced macrophage cells.
Synonyms Retrochalcone
Purity 98.38%
Molecular Weight 270.28
Formula C16H14O4
CAS No. 34221-41-5

Storage

0-4℃ for short term (days to weeks), or -20℃ for long term (months).

Solubility Information

Chloroform: Soluble

DMSO: 49 mg/mL (181.3 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

Citations

References and Literature
3. Yang X, Liu L, Hao Y, et al. An Ultrasensitive Biosensor for Quantifying the Interaction of SARS-CoV-2 and Its Receptor ACE2 in Cells and in vitro[J]. bioRxiv. 2020 4. Hong P, Liu Q W, Xie Y, et al. Echinatin suppresses esophageal cancer tumor growth and invasion through inducing AKT/mTOR-dependent autophagy and apoptosis[J]. Cell Death & Disease. 2020, 11(7): 1-13.

Related compound libraries

This product is contained In the following compound libraries:
Bioactive Compound Library Natural Compound Library for HTS Oxidation-Reduction Compound Library Immunology/Inflammation Compound Library Selected Plant-sourced Compound Library Mitochondrial Targeting Compound Library Polyphenolic Natural Compound Library Food as Medicine Library Anti-aging Compound Library Natural Compoud Library in Chinese Pharmacopoeia Ferroptosis Compound Library Anti-COVID-19 Traditional Chinese Medicine Compound Library Traditional Chinese Medicine Monomer Library Anti-fibrosis Compound Library

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Related compounds with same targets
Sodium 4-aminosalicylate dihydrate Edaravone Rebamipide Isomangiferin Echinatin Rubiadin 2,2,6,6-Tetramethylpiperidinooxy

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